Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. ...

I read the article titled " Fine needle diathermy – A choice for managing corneal vascularization " and written by Thatte S (2011) with great interest as corneal vascularization is a very common problem encountered by us also in Nepal. Most of the cases that we see are healed corneal ulcers with vascularization, in which doing an optical keratoplasty is a big challenge. The author has done a ve...

The transcription factor TBX1 is the major gene involved in 22q11.2 deletion syndrome (22q11.2DS). Using mouse models of these diseases, we have previously shown that TBX1 activates VEGFR3 in endothelial cells (EC), and that this interaction is critical for the development of the lymphatic vasculature. In this study, we show that TBX1 regulates brain angiogenesis. Using loss-of-function genetic...

Current methods for engineering vascularized tissues rely primarily on the self-organization of vascular cells (endothelial cells, pericytes, and smooth muscle cells) or their progenitors in a scaffold and/or on the recruitment of new vessels via release of angiogenic factors [1,2]. While these approaches certainly accelerate the process of graft vascularization, they still require several days...

In this paper we present several ODE systems encoding the most essential observations and assumptions about the complex hierarchical interactive processes of tumor neo-vascularization (angiogenesis). From experimental results we infer that a significant marker of tumor aggressiveness is the oscillatory behavior of tumor size, which is driven by its vascularization dynamics. To study the forces ...

In many disorders of the cornea, blood vessels invade this normally avascular tissue. Several theories have been proposed to explain the pathogenesis of corneal vascularization. Since none had received general acceptance, experimental studies of the phenomenon were begun several years ago in hamster cheek pouch chambers. These investigations which employed sequential morphologic studies during ...

The angiogenic capacity of fibroblasts is maximized through the deliver plasmids and release proteins. Consequentially, endothelial cells proliferate organize, demonstrating potential system where vascularization required.

PURPOSE To estimate cure rate following graft rejection in bilateral corneal transplants in Iranian patients with keratoconus and to determine risk factors associated with rejection. METHODS In this retrospective study, data were compiled from records of patients who had undergone bilateral penetrating keratoplasty (PK) for keratoconus between 1988 and 2007. In order to estimate cure rate in ...

Early vascularization is a prerequisite for successful bone healing and endothelial progenitor cells (EPC), seeded on appropriate biomaterials, can improve vascularization. The type of biomaterial influences EPC function with bioglass evoking a vascularizing response. In this study the influence of a composite biomaterial based on polylactic acid (PLA) and either 20 or 40% bioglass, BG20 and BG...