Ovarian clear-cell carcinoma (OCCC) is an aggressive form of ovarian cancer with high ARID1A mutation rates. Here we present a mutant mouse model of OCCC. We find that ARID1A inactivation is not sufficient for tumour formation, but requires concurrent activation of the phosphoinositide 3-kinase catalytic subunit, PIK3CA. Remarkably, the mice develop highly penetrant tumours with OCCC-like histo...

Surface epithelial stromal tumors account for approximately 60% of all ovarian tumors and approximately 90% of all ovarian malignancies. Sex cord stromal tumors account for 7% of all malignant ovarian tumors. Germ cell tumors make up only 3-7% of malignant ovarian tumors. A combination of serous carcinoma of the ovary and choriocarcinoma is rare. Until today such combination has been documented...

122 patients who presented with or developed calcification within metastatic ovarian cancer. Changes in soft tissue lesion size and the development of calcification have been correlated with histopathology and outcome. The study group was compared with a control group of 1577 patients who had a CT scan performed at least once during follow-up. A positive relationship between calcification and t...

BACKGROUND The present study was conducted to assess whether cytology can help in rapid diagnosis of ovarian neoplasms and thus facilitate individualised treatment. METHODS A prospective investigation was performed on 30 cases of suspected ovarian neoplasms. Imprint smears were made intraperatively from fresh samples from various representative areas, and stained with Leishman Giemsa for air-...

Growing teratoma syndrome (GTS) an extremely rare phenomenon complicatingmalignant ovarian germ cell tumours. Till date very few have been reported. Growing teratoma syndrome (GTS) is characterised by increase in the size of a tumour occurringduring or after chemotherapy for mixed germ cell tumour. Complete surgical resection not only confirms the diagnosis, revealing mature teratoma component,...

INTRODUCTION The diagnosis of hydatid cyst in female genital tract is rare and difficult. A high degree of clinical suspicion is needed for pre-operative investigations to exclude hydatid cyst of female pelvis. The objective of this presentation is to highlight a pelvic hydatid cyst that presented as an ovarian tumour. CASE PRESENTATION A 22-year-old female, presented with constipation and ha...

Approximately 60% of all ovarian tumors are epithelial in origin, and these neoplasms are thought to arise from the ovarian surface epithelium or small epithelial inclusion cysts. Surface epithelium is capable of differentiating into serous (tubal), mucinous, endometrioid or transitional epithelium. Serous and mucinous cystadenomas are the most common epithelial tumors and, together, account fo...

Background: Ovarian lesions are one of the most frequent lesions in women .The pre-operative diagnosis relies mainly on clinical and radiological findings while post-operative diagnosis is made by histo-pathological examination. With the advent of accurate imaging techniques like USG and CT scan, guided FNAC can prove to be an efficient diagnostic modality for ovarian neoplasm. Aims & Objective...

BACKGROUND Ovarian cancer is the eighth leading cancer in women, as it accounts for 4% of all malignant tumors in females. The incidence of ovarian cancer is up to 10 times higher in western countries than in rural Asian and Africa ones. Different reproductive characteristics, life styles and specific medical conditions are responsible for different pattern and incidence of ovarian cancer world...