PURPOSE Elevated metabolic activity of ovarian cancer cells causes increased ubiquitin-proteasome-system (UPS) stress, resulting in their greater sensitivity to the toxic effects of proteasomal inhibition. The proteasomes and a potentially compensatory histone deacetylase 6 (HDAC6)-dependent lysosomal pathway mediate eukaryotic protein turnover. We hypothesized that up-regulation of the HDAC6-d...

Background: Follicular pool is reduced after transplantation of vitrified ovary. Therefore, methods should be improved to accelerate ovarian function revival and maintain follicular reserve. In this study hyaluronic acid hydrogel as a scaffold was used to improve restoration of ovarian oestrous cycle. Materials and Methods: 79 mature (~8 weeks) rats having normal estrous cycles were divided int...

The optimal adjuvant endocrine therapy in premenopausal women with early-stage breast cancer is yet to be elucidated. Studies have demonstrated that women who experience cessation of ovarian function after chemotherapy (chemotherapy-induced amenorrhea) may experience improved survival. These findings, however, have not been replicated when pharmacologic or surgical interventions have been used ...

This review outlines the current understanding of ovarian endocrine development and regulation with both physiological and biochemical background to provide a framework applicable to problems concerning environmental agents and ovarian endocrine function. Two approaches are used. First, the endocrine regulation of follicle development and corpus luteum function is considered in the classical se...

background: aqueous extract of winter cherry ( physalis alkekengi l; family of solanaceae) fruits (wcf) has long been recommended for fertility control by herbalists in iran. the effect of this extract on lowering serum progesterone levels has been reported previously.   objective: to study the effects of wcf extract on the activities of ovarian 3β-hydroxysteroid dehydrogenase (3β-hsd) responsi...

There is still not enough evidence that endometriosis per se and infertility are causally related. While extensive pelvic adhesions or the loss of ovarian tissue clearly bears out the causative role of endometriosis this is more difficult in other patients. Several randomized controlled trials and observational studies have in fact reported almost uniform negative results: • spontaneous pregnan...

The Hippo pathway is dysregulated in multiple types of human cancer, including ovarian cancer. Nuclear expression of yes-associated protein 1 (YAP1), a downstream transcription coactivator of the Hippo pathway, has been demonstrated to promote tumorigenesis in ovarian cancer and may serve as a poor prognostic indicator. However, transcriptional coactivator with PDZ binding motif (TAZ), a downst...

Endometrioma is defined as an ovarian pseudocyst arising from growth of ectopic endometrial tissue, which progressively invaginates the ovarian cortex . Nearly17-44% of women with endometriosis also have endometriomas. Whereas detection of peritoneal endometriosis and adhesions typically requires laparoscopic assessment of the pelvis, endometriomas can be reliably diagnosed by transvaginal ultr...