نتایج جستجو برای: ovarian activity

تعداد نتایج: 1209255  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Andrew J Li Rae Lynn Baldwin Beth Y Karlan

PURPOSE Epidemiological evidence implicates a heightened androgenic state in women with epithelial ovarian cancer. Androgen activity may be modulated by altered expression or activity of the androgen receptor (AR) or AR polymorphisms. Exon 1 of the AR gene contains a polymorphic (CAG)(n) sequence whose length is inversely correlated with transcriptional activity. EXPERIMENTAL DESIGN Different...

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2013
FANG JI YOU WANG LIHUA QIU SHU LI JING ZHU ZHOU LIANG YINSHENG WAN WEN DI

This study investigated the role of LOX in promoting invasion and metastasis of epithelial ovarian cancer in a hypoxic environment and its specific signal transduction pathway. Immunohistochemical detection of HIF-1α and LOX protein expression was performed on formalin-fixed paraffin sections of normal ovary, benign ovarian tumors, borderline and malignant epithelial ovarian tumor paraffin samp...

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Journal: Iranian J. of Fisheries Science 2010
A. Matinfar A. Mohagheghi Samarin B. Abtahi B. Mojazi Amiri I. Pusti M. Bahre Kazemi, M. Soltani

  The aims of the present study were to determine the best time for egg stripping after ovulation and to study oocyte over-ripening in the Caspian brown trout (Salmo trutta caspius). Eggs were retained in the female abdominal cavity for 40 days post ovulation (DPO). Partial volumes of eggs stripped from 10 individually identified females at 10 days intervals and fertilized with a pool of semen ...

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Journal: :Arthropod structure & development 2002
Shannon Hinson Rod N Nagoshi

The doublesex-dependent sex regulatory pathway in Drosophila controls major aspects of somatic sexual differentiation, but its expression is not required in the X/X germline. Nevertheless, mutations in doublesex and in the genes that directly regulate its expression, transformer and transformer-2, disrupt early stages of oogenic differentiation to produce gonads containing immature germ cells. ...

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Journal: :Molecular cancer therapeutics 2006
Xiaozhong Qian William J LaRochelle Gulshan Ara Frank Wu Kamille Dumong Petersen Annemette Thougaard Maxwell Sehested Henri S Lichenstein Michael Jeffers

Histone deacetylase inhibitors represent a promising new class of anticancer agents. In the current investigation, we examined the activity of PXD101, a potent histone deacetylase inhibitor, used alone or in combination with clinically relevant chemotherapeutics (docetaxel, paclitaxel, and carboplatin), in preclinical in vitro and in vivo models of ovarian cancer. In vitro activity was examined...

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2017
Pinar Kanlikilicer Bulent Ozpolat Burcu Aslan Recep Bayraktar Nilgun Gurbuz Cristian Rodriguez-Aguayo Emine Bayraktar Merve Denizli Vianey Gonzalez-Villasana Cristina Ivan Ganesh L.R. Lokesh Paola Amero Silvia Catuogno Monika Haemmerle Sherry Yen-Yao Wu Rahul Mitra David G. Gorenstein David E. Volk Vittorio de Franciscis Anil K. Sood Gabriel Lopez-Berestein

Despite substantial improvements in the treatment strategies, ovarian cancer is still the most lethal gynecological malignancy. Identification of drug treatable therapeutic targets and their safe and effective targeting is critical to improve patient survival in ovarian cancer. AXL receptor tyrosine kinase (RTK) has been proposed to be an important therapeutic target for metastatic and advanced...

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Journal: :Cancer research 2015
Michelle L Stewart Pablo Tamayo Andrew J Wilson Stephanie Wang Yun Min Chang Jong W Kim Dineo Khabele Alykhan F Shamji Stuart L Schreiber

Decitabine, a cancer therapeutic that inhibits DNA methylation, produces variable antitumor response rates in patients with solid tumors that might be leveraged clinically with identification of a predictive biomarker. In this study, we profiled the response of human ovarian, melanoma, and breast cancer cells treated with decitabine, finding that RAS/MEK/ERK pathway activation and DNMT1 express...

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Journal: :Psycho-Oncology 2009

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Journal: :Molecular and cellular endocrinology 1998
S Kol I Ben-Shlomo D W Payne M Ando R M Rohan E Y Adashi

Ovulation may constitute a cyclic, inflammatory-like process, wherein the increased expression of interleukin (IL)-1 and the biosynthesis of prostaglandins may be established corollaries. In this communication we hypothesize that glucocorticoids, potent anti-inflammatory principles, may exert an antiovulatory effect by interfering with ovarian IL-1-driven prostaglandin biosynthesis. To test thi...

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Journal: :Molecular cancer research : MCR 2015
Tomoyuki Sasano Seiji Mabuchi Hiromasa Kuroda Mahiru Kawano Yuri Matsumoto Ryoko Takahashi Takeshi Hisamatsu Kenjiro Sawada Kae Hashimoto Aki Isobe Joseph R Testa Tadashi Kimura

UNLABELLED The aim of this study was to determine the role of AKT as a therapeutic target in ovarian clear cell carcinoma (CCC), an aggressive, chemoresistant histologic subtype of ovarian cancer. AKT activation was assessed by immunohistochemistry (IHC) using human tissue microarrays of primary ovarian cancers, composed of both CCC and serous adenocarcinoma (SAC). The growth-inhibitory effect ...

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