Activation of early response genes by interferons (IFNs) and other cytokines requires tyrosine phosphorylation of a family of transcription factors termed signal transducers and activators of transcription (Stats). The Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) is required for cytokine-induced tyrosine phosphorylation and dimerization of the Stat proteins. In order for IFNs t...

BACKGROUND Adipose tissue is a prominent source of plasminogen activator inhibitor-1 (PAI-1), the primary physiological inhibitor of plasminogen activation. Increased PAI-1 expression acts as a cardiovascular risk factor, and plasma levels of PAI-1 strongly correlate with body mass index (BMI). Elevated serum levels of interleukin-6 (IL-6), an inflammatory cytokine and a member of the glycoprot...

The present study investigates the involvement of the IL-6 family of cytokines, activation of the transcription factor Signal Transducer and Activator of Transcription-3 (STAT3), and the role of Suppressor Of Cytokine Signaling-3 (SOCS3) in regulating excitotoxic neuronal death in vitro. Biochemical evidence demonstrates that in primary cortical neurons and SH-SY5Y neuroblastoma cells, IL-6 cyt...

Bone deterioration is a challenge in long-term spaceflight with significant connections to patients experiencing disuse bone loss. Prolonged unloading and radiation exposure, defining characteristics of space travel, have both been associated with changes in inflammatory signaling via IL-6 class cytokines in bone. While there is also evidence for perturbed IL-6 class signaling in spaceflight, t...

Organisms exposed to the damaging effects of high osmolarity accumulate solutes to increase cytoplasmic osmolarity. Yeast accumulates glycerol in response to osmotic stress, activated primarily by MAP kinase Hog1 signaling. A pathway regulated by protein kinase C (PKC1) also responds to changes in osmolarity and cell wall integrity. C. elegans accumulates glycerol when exposed to high osmolarit...

Oncostatin M (OSM), a pleiotropic cytokine of the gp130 cytokine family, has been implicated in chronic allergic inflammatory and fibrotic disease states associated with tissue eosinophilia. Mouse (m)OSM induces airway eosinophilic inflammation and interstitial pulmonary fibrosis in vivo and regulates STAT6 activation in vitro. To determine the requirement of STAT6 in OSM-induced effects in viv...

This paper is an Editorial for the Special Issue titled “OpenStreetMap as a multidisciplinary nexus: perspectives, practices and procedures”. The largely based on talks presented in 2019 2020 editions of Academic Track at State Map conferences. As such, it represents most pressing relevant issues topics considered by academic community relation to OpenStreetMap (OSM)—a global project aimed crea...

The quality of OpenStreetMap (OSM) data has always been of main concern for use in different projects. In our study, in order to understand the fitness for use of OSM data for a routing and navigation system for people with limited mobility, we have assessed the completeness of OSM data with regards to sidewalk information. Relevant attributes for sidewalk information have been considered, and ...

OpenStreetMap’s (OSM) increasing popularity and density urges researchers on studying its data quality. When this includes comparison with a reference dataset, a data matching is necessary for the comparison to be meaningful, usually performed manually at data preparation stage. We propose an automated matching method specifically designed for OSM in the UK, based on a multi-stage approach that...

OpenStreetMap (OSM), the most popular VGI crowdsourcing project, is an excellent example of an open-license spatial database. But what is the quality of OSM road network datasets compared to authoritative counterparts? Several comparisons of this kind are detailed in literature but these cannot be easily adapted to other scenarios. Developing a generic automated procedure is very challenging. T...