During the past few decades, increased aging of world population has prompted search for novel and improved materials orthopedic implant applications [...]

We report here the genome sequence of a clinical isolate of Staphylococcus aureus from an orthopedic infection. Phenotypically diverse Staphylococcus aureus strains are associated with orthopedic infections and subsequent implant failure, and some are highly resistant to antibiotics. This genome sequence will support further analyses of strains causing orthopedic infections.

peri-implantitis is a site-specifi c infectious disease that causes an infl ammatory process in soft tissues, and bone loss around an osseointegrated implant in function. the etiology of the implant infection is conditioned by the status of the tissue surrounding the implant, implant design, degree of roughness, external morphology, and excessive mechanical load. the microorganisms most commonl...

BACKGROUND AND PURPOSE Hydroxyapatite (HA) coating stimulates the osseointegration of cementless orthopedic implants. Recently, locally released osteogenic growth factors have also been shown experimentally to stimulate osseointegration so that bone fills gaps around orthopedic implants. Here, we have compared the effect of local release of TGF-beta1 and IGF-1 with that of hydroxyapatite coatin...

Despite systemic prophylaxis, infection rates after orthopedic surgery can reach more than 1%. A new HAP/TCP bone substitute loaded with 125 mg of gentamicin was designed for prophylactic use. Its aim was to enhance the efficacy of systemic prophylactic treatments by increasing the local antibiotic concentration. The release rate of gentamicin from the bone substitute was investigated after imp...

Reprogramming somatic cells into an ESC-like state, or induced pluripotent stem (iPS) cells, has emerged as a promising new venue for customized cell therapies. In this study, we performed directed differentiation to assess the ability of murine iPS cells to differentiate into bone, cartilage, and fat in vitro and to maintain an osteoblast phenotype on a scaffold in vitro and in vivo. Embryoid ...

The development of a Ti-34Nb-6Sn alloy by the powder metallurgy method, employing two different compaction conditions, A (100 MPa) and B (200 MPa), was carried out. To evaluate feasibility as an implant biomaterial, microstructural mechanical characterizations, well corrosion susceptibility ion release tests, were performed. Results indicated microstructures dominated presence ?-Ti phase lower ...

background: the success of dental implants depends on the manner in which stresses are transferred to the surrounding bone. an important consideration is to design an implant with a geometry that will minimize the peak bone stresses caused by standard loading. the aim of this study was to assess the infl uence of implant thread geometry on biomechanical load transfer and to compare the differen...

Polyether ether ketone (PEEK) possesses excellent mechanical properties similar to those of human bone and is considered the best alternative material other than titanium for orthopedic spine and trauma implants. However, the deficient osteogenic properties and the bioinertness of PEEK limit its fields of application. The aim of this study was to limit these drawbacks by coating the surface of ...

Polyetheretherketone (PEEK) exhibits appropriate biomechanical strength as well as good biocompatibility and stable chemical properties but lacks bioactivity and cannot achieve highly efficient osseointegration after implantation. Incorporating bioceramics into the PEEK matrix is a feasible approach for improving its bioactivity. In this study, nanohydroxyapatite (n-HA) and nano-calcium silicat...