This letter is a response to the report by Sungur and Güven [1] on intensive care management of organophosphate insecticide poisoning, which was recently published in Critical Care. Insect damage costs the world loses approximately 6 billion pounds sterling every year. Use of pesticides has increased food production in parallel with population growth in many parts of the world. Many insect-born...

Organophosphorus compounds are important in organic chemistry. This review article covers emerging, powerful synthetic approaches to organophosphorus compounds by homolytic substitution at phosphorus with a carbon-centered radical. Phosphination reagents include diphosphines, chalcogenophosphines and stannylphosphines, which bear a weak P-heteroatom bond for homolysis. This article deals with t...

objective the extensive pollution of natural ecosystems has occurred by organophosphorus pesticides, being used for improvement of crop production in agriculture. biodegradation is interested in application of multifunctional bacteria containing genetical elements which specially degrade organophosphorus compounds. in this paper the detection of two bacteria species, pseudomonas and flavobacter...

BACKGROUND Suicide by organophosphorus poisoning is common in India. Study of factors associated with lethality may suggest methods for prevention. METHODS Severity of symptoms, biochemical manifestation of poisoning, degree of lethality and the outcome were studied with an aim to explore the modifiable factors associated with lethality and to discuss preventability. Clinical variables were c...

A soil bacterium capable of metabolizing organophosphorus compounds by reducing the P S group in the molecules was taxonomically identified as Klebsiella sp. strain F51-1-2. The gene involved in the reduction of organophosphorus compounds was cloned from this strain by the shotgun technique, and the deduced protein (named AKR5F1) showed homology to members of the aldo-keto reductase (AKR) super...

inhibitors of soluble epoxide hydrolase (seh) represent one of the novel pharmaceutical approaches for treating hypertension, vascular inflammation, pain and other cardiovascular related diseases. most of the potent seh inhibitors reported in literature often suffer from poor solubility and bioavailability. toward improving pharmacokinetic profile beside favorable potency, two series of 4-benza...

Organophosphorus compounds, used as insecticides and agents of chemical warfare, are a major global cause of health problems. These irreversible inhibitors of cholinesterase produce three well-recognised clinical entities: the initial cholinergic phase, which is a medical emergency often requiring management in an intensive care unit; the intermediate syndrome, during which prolonged ventilator...

This study was conducted to assess oxidative stress and antioxidant status of organophosphorus (OP) poisoning cases before and after therapy with atropine and pralidoxime of north Karnataka (India). For this study 30 male OP poisoning cases (study group) and 30 male normal healthy subjects (control group) having age range 17-40 years were taken. All organophosphorus poisoning cases were diagnos...