The use of organophosphates (pesticides and other compounds to eradicate pests), currently, increase the fulfillment population's consumption needs has a double-edged sword effect, on one hand it can need for food be consumed by population. negative effect that arise is safety organophosphate drugs which contaminate soil water sources around place where are used. effects associated with xenobio...

Three sisters with cassava poisoning are described. A review of the toxic properties of cassava is presented together with discussion on the methods of its preparation, its adverse effects on man, its detoxification in the body, and the treatment of its poisoning.

The biological activity of eight 1-oxa-4-aza-2-silacyclanes with the OSiCH(2)N fragment including 6-membered 2-sila-5-morpholinones (1-3) and 4-acyl-2-silamorpholines (4-6)and previously unknown 7-membered derivatives of salicylic acid (7, 8) was studied. Compounds 1 and 3-6 show the certain antihypoxic action. Compounds 2 (40 mg/kg), 4 (20 mg/kg), 6 (40 mg/kg), 7 (20 mg/kg) and 8 (40 mg/kg) re...

BACKGROUND Radionuclide- and heavy metal-contaminated subsurface sediments remain a legacy of Cold War nuclear weapons research and recent nuclear power plant failures. Within such contaminated sediments, remediation activities are necessary to mitigate groundwater contamination. A promising approach makes use of extant microbial communities capable of hydrolyzing organophosphate substrates to ...

BACKGROUND An estimated 2-3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies. Our aim was to determine the safety of clonidine given as an antidote in adult patients presenting with signs or symptoms of acute organophos...

Birgit Puschner 1,2*, Steven Gallego2, Elizabeth Tor2, Dennis Wilson3, Dirk Holstege4 and Frank Galey5 1Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USA 2California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, Davis, CA, USA 3California Department of Food and Agriculture, Ani...

Two novel mechanisms of organophosphate resistance were isolated and characterized from a population of Culex pipiens L. from Cyprus. Two strains, one expressing the novel, highly active esterases A5 and B5 (strain A5B5-R), and one expressing insensitive acetylcholinesterase (strain Ace-R), were developed by single pair crosses and selection with temephos and propoxur, respectively. The A5B5-R ...

pH-sensitive field effect transistors (FET) were modified with organophosphate hydrolase (OPH) and used for direct detection of organophosphate compounds. OPH is the organophosphate degrading gene product isolated from Pseudomonas diminuta. OPH was selected as an alternative to acetylcholinesterase, which requires inhibition mode sensor operation, enzyme regeneration before reuse, long sample i...