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The structure of a protein can elucidate its function, in both general and specific terms, and its evolutionary history. Extracting this information, however, requires a knowledge of the structure and its relationships with other proteins. These two aspects are not independent, for an understanding of the structure of a single protein requires a general knowledge of the folds that proteins adop...

What is the significance of three-dimensional structural similarity? This fundamental question still remains unanswered in spite of advances in automatic structure comparison methods that have been made in the last few years. The answer to this question will give us a much deeper insight into the principles of protein architecture.

.................................................................................................................................................. II Publications ........................................................................................................................................... III

Comparison of protein structures can reveal distant evolutionary relationships that would not be detected by sequence information alone. This helps to infer functional properties. In recent years, many methods for pairwise protein structure alignment have been proposed and are now available on the World Wide Web. Although these methods have made it possible to compare all available protein stru...

Using Criticality To Attack Performance Bottlenecks

E-learning, one of the tools emerged from information technology, has been integrated in many university programs. There are several factors that need to be considered while developing or implementing university curriculums that oVer e-learning based courses. This paper is intended to specify e-learning critical success factors (CSFs) as perceived by university students. The published e-learnin...

Redundancy-aware learning of protein structure-function relationships

We show that the N = 2 superstring in d = 2D ≥ 6 real dimensions, with criticality achieved by including background charges in the two real time directions, exhibits a " coordinate-freezing " phenomenon, whereby the momentum in one of the two time directions is constrained to take a specific value for each physical state. This effectively removes this time direction as a physical coordinate, le...