PURPOSE Intravenous (IV) saline has been used by athletes attempting to accelerate rehydration procedures. The diuresis from IV rehydration may be circumvented through the concomitant use of oral glycerol. We aimed to examine the effects of rehydrating with four different regimens of IV fluid and oral glycerol on subsequent 40-km cycling time trial performance. METHODS Nine endurance-trained ...

Rosuvastatin calcium (RC), is a hypolipidemic drug, and has poor oral bioavailability of about 20% due to first-pass effect. For improving the oral bioavailability of RC, solid lipid nanoparticles (SLNs) were developed using triglycerides (tristearin, tripalmitin, and trimyristin). Hot homogenization followed by ultrasonication method was used to prepare RC-SLNs. The prepared SLNs were characte...

rapidly disintegrating oral tablets that contain disintegrants, such as microcrystalline cellulose or low substituted hydroxypropylcellulose. However, the main disadvantage of these tablets is a rough feeling in the mouth, because they are water-insoluble. To solve this problem, we used water-soluble sugars as ingredients of rapidly disintegrating oral tablets and developed a preparation method...

The development of a highly sensitive enzyme-linked immunosorbent assay and gas chromatography-mass spectrometry confirmation method for the detection of dextromethorphan and its major metabolite dextrorphan in urine and oral fluid is described. For the screening assay, the intraday precision was less than 8% for urine and less than 5% for oral fluid. The interday precision was less than 10% fo...

Tacrolimus is an immunosuppressive agent used to prevent allograph rejection.1,2 It is available as immediate-release (0.5-, 1-, and 5-mg) or extended-release (0.5-, 1-, 3-, and 5-mg) capsules. The stability of extemporaneous oral suspensions in Ora-Plus/Ora-Sweet and Ora-Plus/syrup has been reported previously.3-6The current study was undertaken to evaluate the stability of tacrolimus in Oral ...

Injuries due to inhalation of hot gas is commonly encountered when dealing with fire and combustible material posing a threat to the human life. Various studies have been carried out in the literature investigating the heat and mass transfer characteristics in the human respiratory tract. This study focuses on assessing the injury taking place in the upper human respiratory tract and identifyin...

NiTi alloys used for orthodontic applications need to show superelastic characteristics at room and oral temperatures. The ideal scenario is that where the material has a final austenitic phase transformation value below the room temperature. This study aims at understanding the influence of the ageing treatments in the austenitic structure at room temperature on a wire of a Ni-rich NiTi alloy ...

The tribology of an open system at temperatures ranging between 3 °C and -35 °C, with and without snow, was investigated using a pin-on-disc tribometer mounted in a temperature-controlled environmental chamber. The relationship between the microstructure and ductility of the materials and the tribology at the contacting surfaces was investigated. The study shows that during continuous sliding, ...