BACKGROUND Children with a diagnosis of cross-reactive hypersensitivity to both paracetamol and nonsteroidal anti-inflammatory drugs are limited in their choice of antipyretics. OBJECTIVE The aim of this pilot study is to evaluate the feasibility of using a Chinese proprietary medicine, Yin Qiao San (YQS), for fever relief. METHODS A single centre, open label, prospective clinical trial exp...

Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promisingneuroprotection action, but it suffers from high first pass metabolism and limited abilityto cross blood brain barrier. Severe gastric toxicity following oral administration furtherlimits its utility. Hence, the aim of this study was to investigate whether ibuprofen loadedmucoadhesive microemulsion (MMEI) could enha...

BACKGROUND Many older people have chronic knee pain. Both topical and oral non- steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat this. Oral NSAIDS are effective, at least in the short term, but can have severe adverse effects. Topical NSAIDs also appear to be effective, at least in the short term. One might expect topical NSAIDs both to be less effective and to have fewer a...

Interactions between anti-inflammatory drugs and anti-diabetic drugs particularly sulphonylureas are known. Nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, phenylbutazone and oxyphenbutazone are known to potentiate (I, 4, 5) and indomethacin and ibuprofen are known to antagonise the hypoglycaemic effect of oral sulphonylurea drugs (2). On the other hand Wellinger et al. (12) reporte...

Classical proinflammatory eicosanoids, and more recently discovered lipid mediators with anti-inflammatory and proresolving bioactivity, exert a complex role in the initiation, control, and resolution of inflammation. Using a targeted lipidomics approach, we investigated circulating lipid mediator responses to resistance exercise and treatment with the NSAID ibuprofen. Human subjects undertook ...