BACKGROUND St. John's wort (Hypericum perforatum L.) is an herbaceous plant that is native to Europe, West Asia and North Africa and that is recognized and used worldwide for the treatment of mild and moderate depression. It also has been shown to be therapeutic for the treatment of burns, bruises and swelling and can be used for its wound healing, antiviral, antimicrobial, antioxidant, analges...

OBJECTIVE To investigate pazopanib hydrochloride, a multitargeted kinase inhibitor, for treatment of choroidal neovascularization (CNV). METHODS Choroidal neovascularization was induced in mice by rupture of Bruch membrane with laser photocoagulation. Mice were treated with pazopanib by gavage or periocular injection, and the area of CNV was measured. RESULTS Twice-daily gavage of pazopanib...

Exogenous administration of islet amyloid polypeptide (IAPP) has been shown to inhibit both insulin and glucagon secretion. This study examined alpha-cell function in mice with beta-cell specific overexpression of human IAPP (hIAPP) after an oral protein gavage (75 mg whey protein/mouse). Baseline glucagon levels were higher in transgenic mice (41 +/- 4.0 pg/mL, n = 6) than in wildtype animals ...

To investigate the pharmacokinetics and pharmacodynamics of Astragali Radix-Corni Fructus herb-pair in kidney-yin deficiency model, which was made by continuously oral gavage thyroxine. A simple rapid LC-MS/MS method developed validated for determination loganin morroniside rat plasma used study. The significantly changed AUC(0-∞), Cmax CLz/F morroniside. T1/2z increased rats. For study, liver ...

This study aims to evaluate the effect of fenugreek on biochemical parameters, body weight, and behavior male Wistar rats. The purpose administering aqueous extract seeds (Trigonella foenum-graecum L) for 30 successive days by oral gavage (force-feeding) at a dose 250g / l water is intended assess, one hand, neurobehavioural effects 'on other hand its some parameters (glycemia lipid balance) as...

OBJECTIVE Glucagon-like peptide-2 (GLP-2) is co-secreted with GLP-1 from gut endocrine cells, and both peptides act as growth factors to expand the surface area of the mucosal epithelium. Notably, GLP-2 also enhances glucose and lipid transport in enterocytes; however, its actions on control of amino acid (AA) transport remain unclear. Here we examined the mechanisms linking gain and loss of GL...