Cellular FLICE (FADD-like IL-1beta-converting enzyme)-inhibitory protein (c-FLIP) is a major resistance factor and critical anti-apoptotic regulator that inhibits tumor necrosis factor-alpha (TNF-alpha), Fas-L, and TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis as well as chemotherapy-triggered apoptosis in malignant cells. c-FLIP is expressed as long (c-FLIP(L)), short (c-FLIP...

The mTOR positively regulates cell proliferation and survival through forming 2 complexes with raptor (mTOR complex 1; mTORC1) or rictor (mTOR complex 2; mTORC2). Compared with the mTORC1, relatively little is known about the biologic functions of mTORC2. This study focuses on addressing whether mTORC2 regulates apoptosis, particularly induced by TRAIL (TNFSF10). Using the mTOR kinase inhibitor...

We describe the design and development of a high-speed 8-channel hybrid integrated optical transceiver package with Clock and Data Recovery (CDR) circuits. The package concept has been developed to be compatible with microprocessor package technology and at the same time allow the integration of low cost, high-performance optical components. A 90nm CMOS optical transceiver chip, 850nm 10Gb/s Ga...

The authors introduce two low-cost, modular, totally self checking (TSC), edge triggered and error propagating (code disjoint) flip-flops: one, a D flip-flop used in TSC and strongly fault secure (SFS) synchronous circuits with two-rail codes, the other a T flip-flop, used in a similar way as the D flip-flop but retaining the error as an indicator until the next presetting, to aid error propaga...

In digital VLSI system the clock distribution network and flip flops are most power consuming components. The reduction of power consumption by clock distribution networks & flip flop makes the total VLSI system as low power VLSI system. In the earlier VLSI system design, different power consumption methods are followed to design the various flip-flops .The SABFF(sense amplifier based flip flop...

Cellular FADD-like interleukin-1beta-converting enzyme inhibitory proteins (c-FLIPs; isoforms c-FLIP long [c-FLIP(L)], c-FLIP short [c-FLIP(S)], and c-FLIP Raji [c-FLIP(R)]) regulate caspase-8 activation and death receptor (DR)-induced apoptosis. In this study, using a combination of mathematical modeling, imaging, and quantitative Western blots, we present a new mathematical model describing c...

The timing elements and clock interconnection Networks such as flip-flops and latches, is One of the most power consuming components in modern very large Scale integration (VLSI) system. The area, power and transistor count will compared and designed using several latches and flip flop stages. Flip Flop is a circuit which is used to store state information. Power consumption is one of the main ...