نتایج جستجو برای: optic effect

تعداد نتایج: 1682311  

2014
Chiara La Morgia Michele Carbonelli Piero Barboni Alfredo Arrigo Sadun Valerio Carelli

Hereditary optic neuropathies are diseases affecting the optic nerve. The most common are mitochondrial hereditary optic neuropathies, i.e., the maternally inherited Leber's hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA). They both share a mitochondrial pathogenesis that leads to the selective loss of retinal ganglion cells and axons, in particular of the papillo-macular bu...

Journal: :Investigative ophthalmology & visual science 2017
Juan Manuel Chao de la Barca Gilles Simard Emmanuelle Sarzi Tanguy Chaumette Guillaume Rousseau Stéphanie Chupin Cédric Gadras Lydie Tessier Marc Ferré Arnaud Chevrollier Valérie Desquiret-Dumas Naïg Gueguen Stéphanie Leruez Christophe Verny Dan Miléa Dominique Bonneau Patrizia Amati-Bonneau Vincent Procaccio Christian Hamel Guy Lenaers Pascal Reynier Delphine Prunier-Mirebeau

Purpose Dominant optic atrophy (MIM No. 165500) is a blinding condition related to mutations in OPA1, a gene encoding a large GTPase involved in mitochondrial inner membrane dynamics. Although several mouse models mimicking the disease have been developed, the pathophysiological mechanisms responsible for retinal ganglion cell degeneration remain poorly understood. Methods Using a targeted me...

2016
Zhen-Hua He Zheng-Bo Lan Ao Xiong Guo-Kuo Hou Ya-Wen Pan Qiang Li Xin-Ding Zhang

PURPOSE Traumatic optic neuropathy (TON) is a serious complication of head trauma with the incidence rate of 0.5%-5%. The aim of this study was to investigate the therapeutic efficacy of endoscopic decompression of the optic canal for optic nerve injuries. METHODS In this study, 11 patients treated in our hospital from January 2009 to January 2015 with the visual loss resulting from TON were ...

فتاحی, مریم , مجیدزاده, سولماز, نوبخت, ملیحه, طباطبایی, پروانه , میرصمدی, منصور ,

    NO is a free radical that regulates a variety of developmental modulation processes. NO is synthesized by NOS and it acts as a neurotransmitter, neuromodulator or second messenger molecule in the central nervous system. Since NO production may be different before or after birth, the expression of neuronal nitric oxide synthase was examined and analysized during the development of rat optic ...

Gh. Parhizgari M. Aminlari, S. Gholami S. Ranjbar

The purpose of this investigation was to study and compare the electrophoretic patterns of optic lensproteins of different species of domestic animals at pre- and post-natal ages. Optic lenses were removed from the embryo or adult sheep, cattle, goat, camel and chicken at the slaughter-house then homogenized and subjected to sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE). I...

2013
Bing Jiang Pu Zhang Dan Zhou Jun Zhang Xiang Xu Luosheng Tang

OBJECTIVES To treat traumatic optic neuropathy (TON) with transplantation of human umbilical cord blood stem cells (hUCBSC) and explore how transplanted stem cells participate in the neuron repairing process. METHODS A total of 195 Sprague-Dawley rats were randomly assigned to three groups: sham-surgery, optic nerve injury, and stem cell transplant group. Optic nerve injury was established in...

Journal: :Cerebral cortex 2006
David J Logan Charles J Duffy

As arboreal primates move through the jungle, they are immersed in visual motion that they must distinguish from the movement of predators and prey. We recorded dorsal medial superior temporal (MSTd) cortical neuronal responses to visual motion stimuli simulating self-movement and object motion. MSTd neurons encode the heading of simulated self-movement in three-dimensional (3-D) space. 3-D hea...

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