PURPOSE The purpose of this study was to correlate high-resolution magnetic resonance imaging (MRI) and histologic findings in a case of juxtapapillary choroidal melanoma with clinical evidence of optic nerve invasion. METHODS With institutional review board approval, an enucleated globe with choroidal melanoma and optic nerve invasion was imaged using a 7-tesla MRI followed by histopathologi...

Optic neuritis is an inflammation of the optic nerve and may be related to different systemic conditions. The clinical presentation of this pathology usually includes sudden loss of visual acuity (VA) which may be unilateral or bilateral, visual field restriction, pain with eye movements, dyschromatopsia, a relative afferent pupillary defect and optic disk swelling. Optic neuritis in children h...

OBJECTIVE To demonstrate the development of subfoveal fluid associated with optic disc swelling from nonarteritic anterior ischemic optic neuropathy. METHODS Optical coherence tomographic studies obtained during a 3-year period (October 1, 2003, to December 30, 2006) from 76 patients who developed ischemic optic neuropathy from 2 institutions were evaluated. The presence or absence, and the d...

The development of optical coherence tomography (OCT) has changed the clinical management of ophthalmic diseases by furthering the understanding of pathogenesis, as well as improving the monitoring of their progression and assisting in quantifying the response to treatment modalities in ophthalmic diseases. Initially, the two-dimensional configuration of the optic nerve head (ONH) and the thick...

The purpose is to study for the first time vascular plexuses and retinal nerve fiber layer raphe of a patient with very uncommon anatomical variation: an anomalous artery supplying whole macula. We used multimodal imaging, en face spectral-domain optic coherence tomography, tomography angiography. One presented in his left eye unusual variation macular vascularization. A deriving from inferior ...

Glaucoma is a progressive, multifactorial optic neuropathy characterised by acquired atrophy of the optic nerve due to the loss of retinal ganglion cells and their axons in the retina. Thus, evaluation of the retinal nerve fibre layer (RNFL) is key to diagnosing and monitoring changes in patients with glaucoma. Until recently, red-free fundus photographs were the clinical standard for evaluatin...

Our goal is to provide an instructional resource to help others wishing to use the optic nerve crush (ONC) as an experimental procedure. The process is described beginning with the anesthesia, followed by positioning of the mouse, the surgery itself, and post-surgical care. We analyzed the effect of ONC on retinal blood flow, using optical coherence tomography doppler. This procedure produces a...

In this study, optical coherence tomography (OCT) was used to evaluate retinal thickness in two patients with optic neuropathy who had recently discontinued ethambutol. OCT was used to measure retinal nerve fiber layer (RNFL) thickness and to map the RNFL, ganglion cell layer (GCL), and inner plexiform layer (IPL). Decreased RNFL thickness was observed in one case. However, the combined RNFL, G...

Objective The aim is to compare the retinal nerve fiber layer (RNFL) thickness of longitudinally extensive transverse myelitis (LETM) eyes without previous optic neuritis with that of healthy control subjects. Methods Over 20 LETM eyes and 20 normal control eyes were included in the study and subjected to optical coherence tomography to evaluate and compare the RNFL thickness. Result Signif...

CASE REPORT This report describes two siblings, a woman aged 44 years and her brother aged 29 years, who both complained of visual loss in both eyes. The woman had bilateral optic nerve (ON) temporal pallor and severe reduction of ON fibre layer thickness in this area. Both she and her brother had cecocentral defects in perimetry and color vision deficiency with a marked tritanopia deficit. D...