purpose : to investigate and compare the causes of blindness in ocular behçet’s disease (bd) in men and women methods : in a retrospective, descriptive investigation from 1976 to 2008, 6,021 bd cases were registered in our bd unit of shariati hospital of tehran university of medical sciences (tums). at the last visit, 187 patients (124 men and 63 women) were blind (vision=1/10 or less) at least...

purpose : to evaluate the correlations between visual field (vf) defects with retinal nerve fiber layer (rnfl) thickness in nonarteritic anterior ischemic optic neuropathy (naion) eyes, compare different gdx parameters with the other healthy contralateral eyes, and calculate receiver operating characteristic (roc) curve for the gdx parameters methods : eighteen patients with unilateral naion fr...

PURPOSE To establish normative magnetic resonance diffusion tensor imaging (MRDTI) data in the pediatric optic nerve and compare to pathologic conditions both intrinsic and extrinsic to the anterior optic nerve pathway. MATERIALS AND METHODS A retrospective analysis of MRDTI at 3.0T in children ages 0-18 with both normal imaging studies and with pathologic conditions either arising from the o...

PURPOSE To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy. METHODS Chronic elevation of rat intraocular pressure (IOP) leading to optic nerve damage was induced by episcleral injection of hypertonic saline, which caused sclerosis and blockade of aqueous humor outflow pathways. Expression of NOS-2 in the retina and optic nerve head (ONH) ...

PURPOSE To investigate optic nerve degeneration associated with CLN3 deficiency in a murine model of juvenile neuronal ceroid lipofuscinosis (Batten disease). METHODS Using light and electron microscopy, the density and diameter of axons and the thickness of myelin in optic nerve were compared between age-matched cln3 knock-out (cln3-/-) and wild-type (129ev/TAC) mice. Western blot analysis w...

The PhD dissertation was carried out at the Eye Pathology Institute, University of Copenhagen, and the Department of Ophthalmology, Rigshospitalet, Copenhagen University Hospital. The aim was to investigate tumours of the optic nerve in a known population. Therefore, we studied all surgically removed tumours of the optic nerve in Denmark during a study period of 25 years. Furthermore, in order ...

EDITOR,—Doubling of the optic disc is rare and can manifest as true or pseudo doubling. A 64 year old man was referred by his physician who noted “a clear area between each optic disc on both sides” during a routine check. Visual acuities and anterior segments were normal. Funduscopy revealed an appearance simulating double optic discs on each side. The right eye showed a 2 disc diameter (DD) s...

A cobalt chloride impregnation technique was applied to the optic nerve in Xenopus tadpoles and the central optic pathways were examined in cleared, whole-mounted preparations, and in thick sections. The overall plan of the optic input was visualized in relation to the outlines of the parts of the brain and details of the structure of the tectal optic neuropil, the neuropil of Bellonci and the ...