Balog, Edward M., Bradley R. Fruen, Patricia K. Kane, and Charles F. Louis. Mechanisms of Pi regulation of the skeletal muscle SR Ca21 release channel. Am. J. Physiol. Cell Physiol. 278: C601–C611, 2000.—Inorganic phosphate (Pi) accumulates in the fibers of actively working muscle where it acts at various sites to modulate contraction. To characterize the role of Pi as a regulator of the sarcop...

Balog, Edward M., Bradley R. Fruen, Patricia K. Kane, and Charles F. Louis. Mechanisms of Pi regulation of the skeletal muscle SR Ca21 release channel. Am. J. Physiol. Cell Physiol. 278: C601–C611, 2000.—Inorganic phosphate (Pi) accumulates in the fibers of actively working muscle where it acts at various sites to modulate contraction. To characterize the role of Pi as a regulator of the sarcop...

Release behavior of hydrogen isotopes thermally sorbed in Li2TiO3 pellet was studied by thermal desorption spectroscopy (TDS). As microstructure (grain size, surface condition, open and closed pores) of pellet samples were changed by high-temperature sintering, the release behavior of hydrogen isotopes was changed. The amount of hydroxyl groups chemically adsorbed on the surface was found to in...

We have studied the effects of clinically useful anthraquinones on the cardiac sarcoplasmic reticulum calcium-release channel. Micromolar concentrations of doxorubicin and other anthracyclines at the cytosolic face of the channel significantly and reversibly increase the open probability of single channels in artificial phospholipid bilayers. Lifetime analysis shows that anthracyclines and calc...

in the present study, floating drug delivery beads (fdds) were prepared with sodium alginate/ starch blend as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride solution as a hardening agent. in order to prepare the beads with different porosity and morphology the ratio between pore forming agent to polymer blend and ratio of the consti...

background: repeated applications of animal manure as fertilizer are normal agricultural practices in malaysia that may release veterinary antibiotics to environment from treated animals. methods: environmental risk assessment (era) on 5 commonly used antibiotics and one hormone in malaysian broiler farm was calculated using the ratio of measured environmental concentration (mec) and predicted ...

Diastolic waves of Ca(2+) release have been shown to activate delayed afterdepolarizations as well as some cardiac arrhythmias. The aim of this study was to investigate whether increasing ryanodine receptor open probability alone or in the presence of beta-adrenergic stimulation produces diastolic Ca release from the sarcoplasmic reticulum (SR). When voltage-clamped rat ventricular myocytes wer...