This study was undertaken to evaluate the therapeutic effects of topical ozonated olive oil on acute cutaneous wound healing in a guinea pig model and also to elucidate its therapeutic mechanism. After creating full-thickness skin wounds on the backs of guinea pigs by using a 6 mm punch biopsy, we examined the wound healing effect of topically applied ozonated olive oil (ozone group), as compar...

Wound infections are a serious medical problem for patients with non-healing chronic wounds and burn injuries. The healing of these wounds is often compromised by colonisation of many different bacteria, predisposing patients to life-threatening infections. Infected wounds continue to represent a complex problem for both health professionals and patients. Bacterial infections are a critical com...

Digital vasculopathy and subsequent digital ulceration are common and painful complications of limited cutaneous systemic sclerosis. Although the use of hydrocolloid occlusive dressings has been found to reduce pain, frequently required surgical or chemical debridement can be intensely painful in such ulcers. Acoustic pressure wound therapy is a noncontact, low-frequency ultrasound therapy used...

Objective: Cutaneous wound healing involves multiple cooperative molecular processes such as inflammation, angiogenesis, wound contraction, granulation tissue formation, reepithelialization, and matrix deposition. We studied the effects of topical estrogen on wound healing in male rats. Methodology: This experimental study was done on 40 male rats. A circular wound with a diameter of 2cm was in...

Wound healing, angiogenesis, and hair follicle maintenance are often impaired in the skin of diabetic patients, but the pathogenesis has not been well understood. Here, we report that circulation levels of kallistatin, a member of the serine proteinase inhibitor (SERPIN) superfamily with antiangiogenic activities, were elevated in type 2 diabetic patients with diabetic vascular complications. T...

The sex hormones oestrogen and testosterone are important mediators of wound repair. Oestrogen enhances wound healing by reducing inflammation and enhancing matrix production. However, in post-menopausal women, when oestrogen levels are decreased, wound healing is impaired and susceptibility to chronic non-healing wounds increases. Surprisingly, although the speed of healing is impaired, an imp...

patients and methods the study population consisted of all patients with type iiia gastilo open fractures of tibial shaft, with or without fibula fracture (caused by trauma). after wound irrigation, debridement, and wound swab sampling for microbial culture, all patients received prophylactic antibiotic regimens in fitting with their wound class. no topical antibiotics were used with a 6-month ...

The evolution of cutaneous open wounds was evaluated in five client-owned dogs treated with photodynamic therapy (PDT), mediated by methylene blue and phototherapy light-emitting diodes (LED) as the light source. On first day treatment, wound irrigated sterile 0.9% sodium chloride solution, surface dried, 3% solution hydrogen peroxide soaked for 1 minute. mechanically removed and, immediately a...

background and objectives: accelerating wound healing is a very important factor for patients to return to ordinary life. laser seems to have positive effect on cutaneous wound healing. this study aimed to investigate the effect of red light laser 630 nm on cutaneous surgical wound in hamster and to compare outcomes such as angiogenesis, number of fibroblasts and collagen formation in intervent...

BACKGROUND There are several applications of electrical stimulation described in medical literature to accelerate wound healing and improve cutaneous perfusion. This is a simple technique that could be incorporated as an adjunctive therapy in plastic surgery. The objective of this review was to evaluate the results of randomized clinical trials that use electrical stimulation for wound healing....