Schizophrenia and bipolar disorders share not only clinical features but also some risk factors such as genetic markers and childhood adversity, while other risk factors such as urbanicity and obstetric complications seem to be specific to schizophrenia. An intriguing question is whether the wellestablished abnormal neurodevelopment present in many children and adolescents who eventually develo...

This article focuses on the limitations of contemporary psychopathology which appear to diminish the feasibility of early detection and prevention of the schizophrenia-spectrum disorders. Basically, there are three options for early intervention: (a) intervening early in the course of psychosis, to reduce its duration and potential sequelae; (b) intervening in the ‘prodromal’ phase, to prevent ...

UNLABELLED The aim of the study was to investigate the gender differences in patients with schizophrenia in age of onset, other demographic and clinical characteristics and their relationship with QEEG power spectrum measures. MATERIAL AND METHODS Thirty patients with schizophrenia were enrolled in the study, 17 female and 13 male, mean age 34 years. Comprehensive assessment of the symptoms o...

BACKGROUND The rs10761482 polymorphism of the ANK3 gene has been associated with the occurrence of schizophrenia. AIM Assess the relationship between the ANK3 gene and schizophrenia in individuals of Uyghurian descent. METHODS A total of 630 patients with schizophrenia and 535 healthy controls of Uyghur descent were genotyped for the ANK3 gene rs10761482 locus using Taqman probe technology....

Auditory P300 amplitude reductions are well-established in young adults with schizophrenia. Little is known, however, regarding the P300 in older schizophrenia patients, especially those with late onset. We studied 28 middle-aged and elderly (mean age = 62.7 years) patients [14 with early onset schizophrenia (EOS) and 14 with late onset schizophrenia (LOS)] and 14 normal comparison (NC) partici...

This paper reviews the concept and recent studies on childhood and adolescent psychoses with special reference to schizophrenia. After a short historical introduction, the definition, classification, and epidemiology of child- and adolescent-onset psychoses are described, pointing out that some early-onset psychotic states seem to be related to schizophrenia (such as infantile catatonia) and ot...

Psychosis secondary to traumatic brain injury (PSTBI) is rare yet a serious sequela of (TBI).We provide critical literature review on PSTBI, outlining clinical features and approach the diagnosis treatment. Finally, we illustrate case description, discuss its conceptual framework. Conceptualizing PSTBI as neurobiological syndrome has relevance, insofar as, it facilitates rational scheme, by whi...

P300 event-related potential in late-onset schizophrenia The P300 event-related potential (ERP) is a late positive waveform that is typically maximal at centroparietal midline sites 300 msec post-stimulus in simple categorization tasks. Reduction in auditory P300 amplitude has been widely reported in young schizophrenic patients. The degree of amplitude reduction has been related to the degree ...

BACKGROUND Prepulse inhibition of the startle reflex response refers to the ability of a weak prestimulus to transiently inhibit the response to a closely following strong sensory stimulus. This effect represents an operational index of sensorimotor gating and is found to be deficient in schizophrenia. Prepulse inhibition deficits in schizophrenia seem to be partially normalized by typical anti...

BACKGROUND Identifying neurocognitive subtypes in schizophrenia may help establish neurobiologically meaningful subtypes of the disorder, but is frequently confounded by differences in intellectual function between individuals with schizophrenia and controls. AIMS To examine neuropsychological performance in individuals with epidemiologically based, first-onset schizophrenia and intellectuall...