Synapse loss correlates with cognitive decline in aging and most neurological pathologies. Sensory perception changes often represent subtle dysfunctions that precede the onset of a neurodegenerative disease. However, a cause-effect relationship between synapse loss and sensory perception deficits is difficult to prove and quantify due to functional and structural adaptation of neural systems. ...

BACKGROUND AND AIMS Mutations reducing the function of Nav1.7 sodium channels entail diminished pain perception and olfactory acuity, suggesting a link between nociception and olfaction at ion channel level. We hypothesized that if such link exists, it should work in both directions and gain-of-function Nav1.7 mutations known to be associated with increased pain perception should also increase ...

Sniffing has historically been considered an olfactory behavior because inhalation is a necessary step in odor perception. Growing evidence, however, has demonstrated that the display of sniffing surpasses the bounds of those contexts that are olfactory in nature. In this issue of Chemical Senses, Arzi, Shedlesky, Secundo, and Sobel demonstrate that humans mimic visually and auditory-observed s...

Loss of olfactory function is often the first and only symptom an acute COVID-19 infection. A persistent loss smell also expression a long-COVID syndrome. Those affected complain long-lasting distorted odor perception, which occurs later in course can severely impair quality life.

Sniffing has historically been considered an olfactory behavior because inhalation is a necessary step in odor perception. Growing evidence, however, has demonstrated that the display of sniffing surpasses the bounds of those contexts that are olfactory in nature. In this issue of Chemical Senses, Arzi, Shedlesky, Secundo, and Sobel demonstrate that humans mimic visually and auditory-observed s...

Natural odors, generally composed of many monomolecular components, are analyzed by peripheral receptors into component features and translated into spatiotemporal patterns of neural activity in the olfactory bulb. Here, we will discuss the role of the olfactory cortex in the recognition, separation and completion of those odor-evoked patterns, and how these processes contribute to odor percept...

OBJECTIVES The review outlines characteristics of the intranasal trigeminal chemosensory system. In addition, it provides selective comparisons of the trigeminal and olfactory systems, the two of which interact at multiple levels. RESULTS AND CONCLUSIONS This interaction between the trigeminal and olfactory systems is an important determinant of sensations of odor. Further, it appears to chan...