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[Purpose] This study compared trunk acceleration ratios in old-old adult females during stair negotiation. [Subjects and Methods] Twelve old-old adult females who could walk independently volunteered for this study. This study measured gait time and trunk acceleration ratios using an accelerometer during ascending and descending stairs [Results] The trunk acceleration ratio when descending stai...

Aging is associated with an increase in oxidative stress and blood pressure (BP). Renal dopamine D1 (D1R) and angiotensin II AT1 (AT1R) receptors maintain sodium homeostasis and BP. We hypothesized that age-associated increase in oxidative stress causes altered D1R and AT1R functions and high BP in aging. To test this, adult (3 mo) and old (21 mo) Fischer 344 × Brown Norway F1 rats were supplem...

1. Our purpose was to compare the susceptibilities of muscles in animals of different ages to the injuries induced by stretching the contracting muscle. Single stretches provide an effective method for studying the factors that contribute to the initiation of contraction-induced injury. We hypothesized that, for maximally activated muscles in old compared with young or adult mice, the work inpu...

The hyperlipidemia associated with aging was characterized in the rat by comparing the plasma lipid, lipoprotein, and apolipoprotein profiles of adult (12 weeks old) and old (96 weeks old) male rats. Compared with those of the adult rats, the VLDL concentrations of the old rats were reduced, but IDL, LDL, and HDL concentrations were elevated. Despite a reduced VLDL concentration, concentrations...