Pioglitazone is an anti-diabetic drug in high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes) which was belongs to poor aqueous solubility and bioavailable drug. By using β Cyclodextrin, the solubility and dissolution rate of Pioglitazone HCL can be enhanced and it was evaluated by synthesizing it into solid inclusion complexes in different ratio of drug: β cyclode...

In this study, our aim was to develop solid drug-cyclodextrin inclusion complex system having nanofibrous morphology in order to have fast-dissolving property and enhanced water-solubility of poorly water-soluble drug. Here, we prepared a highly concentrated aqueous solution of inclusion complex between sulfisoxazole and sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD, Captisol®), and then, with...

Abstract: Introduction: The present study was carried out to formulate and evaluate orodispersible tablets of Apremilast with a purpose providing better patient compliance geriatric, pediatric, impaired, travelling non-cooperative patients suffering from psoriasis. Such are in need fast easy swallowing drug delivery system. Materials Methods: Apremilast-β-cyclodextrin inclusion complex prepared...

the interaction of brilliant green with herring sperm dna was investigated in detail by spectrometric methods in γ-cyclodextrin systems. on the condition of physiological ph, brilliant green prefers to form the 1:1 inclusion complex with γ-cyclodextrin.all the evidences indicated that the binding modes between γ-cyclodextrin-brilliant green and dna were grooving binding and partial non-classica...

Background: Hydrolysis of 2-amino phenylpropionitrile by nitrilase is a fundamental biochemical reaction that produces chiral phenylalanine. For practical application of this biochemical reaction, researchers have attempted to improve enzyme enantioselectivity and the reaction rate. Results: The substrate concentration was increased from 100 to 200 mM without substrate inhibition because of the...

In the present work, the sublimation of crystalline solid 2-(2-nitrovinyl) furan (G-0) in the temperature range of 35 to 60 °C (below the melting point of the drug) was studied using thermogravimetric analysis (TGA). The sublimated product was characterized using Fourier-transformed-infrared spectroscopy (FT-IR) and thin layer chromatography (TLC). The sublimation rate at each temperature was o...

In the face of a growing human population and increased urbanization, the demand for pesticides will simply rise. Farmers must escalate yields on increasingly fewer farm acres. However, the risks of pesticides, whether real or perceived, may force changes in the way these chemicals are used. Scientists are working toward pest control plans that are environmentally sound, effective, and profitab...