Ocular drug delivery is a very challenging area for ophthalmologists and scientists due to the structural barrier complexity of eye. Barriers such as different layers cornea, sclera, conjunctival blood flow, tear dilution limit efficacy anterior part eye in addition more barriers present posterior part. Due these, have designed studied various systems increase treatment Among conventional ocula...

PURPOSE To study the role of free radicals in autoregulation of retinal blood flow (RBF) and choroidal blood flow (ChBF) and the contribution of the cyclooxygenase pathway in free radical formation during blood pressure changes in 1- to 3-day-old pigs. METHODS Blood pressure was adjusted by inflating balloon-tipped catheters placed at the aortic isthmus and the aortic root to induce hypertens...

PURPOSE Alprostadil, a prostaglandin (PG)E(1) analogue and pentoxifylline, an alkylxanthine derivate, have been shown to exert vasodilatory effects in several vascular beds. The purpose of the present study was to investigate the effect of PGE(1) and pentoxifylline on the ocular circulation. METHODS A placebo-controlled, double-masked, three-way, crossover study was performed in 15 healthy ma...

The effects of visual stimulation on the cerebral blood flow were studied in pretrigeminal cats. The visual stimulus was a feather duster which was moved for 4-5 min in front of the cats eyes. The cerebral blood flow was measured each 15 min with [133]Xe clearance method in the left occipital lobe. The visual stimulation evoked an increase of the cerebral blood flow which was accompanied by an ...

BACKGROUND The conjunctival microcirculation has potential as a window to cerebral perfusion due to related blood supply, close anatomical proximity and easy accessibility for microcirculatory imaging technique, such as sidestream dark field (SDF) imaging. Our study aims to evaluate conjunctival and sublingual microcirculation in brain dead patients and to compare it with healthy volunteers in ...

PURPOSE To investigate ocular blood flow and visual function in the Ins2(Akita) diabetic retinopathy mouse model at early and late time points after onset of hyperglycemia. METHODS Mice heterozygous for the Ins2(Akita) mutation, which become hyperglycemic at approximately 4 weeks old, were studied at 2.5 and 7.5 months of age, with age-matched wild-type littermates used as controls. Retinal a...