BACKGROUND Reported data regarding intraocular lymphoma (IOL) management are anecdotal. Cases of IOL included in an international multicentre series of 378 immunocompetent patients with primary central nervous system lymphomas (PCNSLs) were reviewed. PATIENTS AND METHODS Staging included slit-lamp examination in 170 patients: IOL was diagnosed in 22 cases (13%). A concomitant brain lesion was...

PURPOSE Changes in concentrations of acute phase proteins in the serum of patients might be significant in the pathogenesis of Behçet disease. This report investigates the association between ocular disease activity and serum haptoglobin levels in patients with Behçet disease, and summarizes the current understanding of the correlation between acute phase proteins and Behçet disease based on bo...

PURPOSE An important phase in the development of an ocular herpes simplex virus type 1 (HSV-1) subunit vaccine is the identification of an efficient, safe, and adjuvant-free antigen delivery system capable of inducing and sustaining long-term memory T-cell protective immunity. This study was conducted to test the hypothesis that immunization with self-adjuvanting lipopeptide bearing HSV-1 glyco...

Background Sarcoidosis constitutes one of the leading causes of ocular inflammation. Chronic ocular sarcoidosis can affect any segment of the eye and its adnexa, producing a wide range of clinical manifestations and severity. If left untreated, permanent visual impairment or even blindness may ensue. Treatment approaches vary from topical therapy to systemic agents that induce immunosuppression...

tuberculosis is an infection which may influence many organs while ocular tuberculosis (tb) is amongst the rarest infectious diseases with no sign of systemic disease. a fifty-six-year- old female with complaint of gradual loss of visual acuity, weight loss, night sweats and purulent discharge from medial canthus and non-productive coughs. in general, tuberculosis in endemic areas, even the rar...

OBJECTIVE To compare the Po(2) distribution in different regions in the eyes of patients undergoing intraocular surgery. METHODS Before initiation of intraocular cataract and/or glaucoma surgery, an optical oxygen sensor was introduced into the anterior chamber via a peripheral corneal paracentesis. The tip of the flexible fiberoptic probe was positioned by the surgeon for 3 measurements in a...

Stickler's syndrome is a congenital disease of connective tissue with considerable ocular and non-ocular lesions. This study reports 12 pedigrees (10 families and two isolated cases) and evaluates some peculiar ocular aspects not previously reported in the syndrome.

Marfan syndrome (MFS) is a genetic disorder which is inherited by autosomal dominant traits. In MFS, lens displacement and cardiovascular involvement are important causes of morbidity and mortality in the clinical course of the disease. In this case study, the ocular involvement in a family with severe penetration of MFS is reported. Twelve members of a family (father, two daughters, three sons...

PURPOSE To evaluate the ocular presentation, treatment, and clinical course of graft-versus-host disease (GVHD). DESIGN Retrospective case series. PARTICIPANTS Two hundred and forty-nine patients with systemic GVHD were included in the study. METHODS Ocular and systemic data were collected from 2003 to 2013. MAIN OUTCOME MEASURES Mortality, visual acuity, and response of ocular symptoms...