AIMS Recent study suggests that algorithms such as the Duke Clinical score (DCS) may overestimate the pretest probability. The Agatston score representing the grade of coronary artery calcification can be simply calculated from low-radiation exposure ECG-gated plain CT. In this study, we investigated whether or not more superior diagnostic performance for obstructive coronary artery disease (CA...

Aim . To study the levels of pro-inflammatory biomarkers in patients with obstructive and non-obstructive coronary artery disease (CAD), to identify possible differences for diagnosing degree obstruction. Material methods The observational included two groups patients: (main group, stenosis <50%; n=30) (comparison hemodynamically significant according results angiography; CAD. interleukin-1β...

Coronary artery disease (CAD) and obstructive sleep apnea (OSA) are both complex and significant clinical problems. The pathophysiological mechanisms that link OSA with CAD are complex and can influence the broad spectrum of conditions caused by CAD, from subclinical atherosclerosis to myocardial infarction. OSA remains a significant clinical problem among patients with CAD, and evidence sugges...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): State Research for Turku University Hospital. Background Coronary computed tomography angiography (CCTA) is recommended diagnostic workup coronary artery disease (CAD) and known to provide prognostic information. However, it unknown whether there time-dependent variation in the str...

PURPOSE Several studies have suggested that a combined approach of stress myocardial perfusion imaging (MPI) and coronary computed tomography angiography (CCTA) can provide diagnostic results with excellent accuracy. We aimed to explore whether the addition of CCTA to stress MPI provides incremental diagnostic value in intermediate-to-high cardiovascular risk patients. METHODS A total of 106 ...

Abstract Funding Acknowledgements Type of funding sources: None. Background Stress computed tomography perfusion (Stress-CTP) is a functional technique that can be added to coronary angiography (cCTA) improve the management patients with suspected artery disease (CAD). Purpose To determine impact routine availability Stress-CTP cCTA in terms downstream testing, radiation exposure and outcome hi...

Heart disease is the leading cause of premature death for women in Canada. Ischemic heart (IHD) categorized as myocardial infarction (MI) with no obstructive coronary artery (MINOCA), ischemia arteries (INOCA), and atherosclerotic (CAD) MI (MI-CAD) or without (non-MI CAD). This study aims to prevalence traditional non-traditional IHD risk factors their relationships (M)INOCA compared MI-CAD non...

OBJECTIVE To assess the prognostic value of low-dose 64-slice coronary CT angiography (CCTA) using prospective ECG triggering in a patient population with known or suspected coronary artery disease (CAD). DESIGN Longitudinal follow-up study. SETTING Tertiary referral cardiac imaging centre. PATIENTS 434 consecutive patients who were referred for evaluation of CAD by CCTA. METHODS The pr...

OBJECTIVE We established the Leipzig (LIFE) Heart Study, a biobank and database of patients with different stages of coronary artery disease (CAD) for studies of clinical, metabolic, cellular and genetic factors of cardiovascular diseases. DESIGN The Leipzig (LIFE) Heart Study (NCT00497887) is an ongoing observational angiographic study including subjects with different entities of CAD. Cohor...

BACKGROUND Sex differences in early mortality after myocardial infarction (MI) vary by age. MI with nonobstructive coronary arteries (MINOCA [<50% stenosis]) is more common among younger patients and women, and MINOCA has a better prognosis than MI with obstructive coronary artery disease (MI-CAD). The relationship between age, sex, and obstructive CAD status and outcomes post-MI has not been e...