It has been widely suggested that the many degrees of freedom of the musculoskeletal system may be exploited by the CNS to minimize energy cost. We tested this idea by having subjects making point-to-point movements while grasping a robotic manipulandum. The robot created a force field chosen such that the minimal energy hand path for reaching movements differed substantially from those observe...

Background: The glutathione S-transferase (GST) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. The expression of many of these cancer susceptibility enzymes is genetically polymorphic. An increased frequency of GST-null genotypes has been associated with several malignancies. Objective: To investigate the rate of GSTT1 and GSTM1 null ge...

We test the presence of a change of slope in a logistic regression model with covariate measured with errors. Under the null hypothesis of no change-point, estimation of a single intercept and slope can be carried out straightforwardly by various conditional score based methods. If the alternative hypothesis holds and indeed there exists a change-point, estimation becomes more challenging, neve...

In this article, we study the local null-controllability for some quasi-linear phase-field systems with homogeneous Neumann boundary conditions and an arbitrary located internal controller in frame of classical solutions. order to minimize number control forces, prove Carleman inequality associated linear system. By constructing a sequence optimal problems iteration method based on parabolic re...

Abstract. In this note we study the geometry of principally polarized abelian varieties (ppavs) with a vanishing theta-null (i.e. with a singular point of order two and even multiplicity lying on the theta divisor) — denote θnull the locus of such ppavs. We describe the locus θ null ⊂ θnull where this singularity is not an ordinary double point. By using theta function methods we first show θ n...

Background: HLA-G gene contains 15 alleles including a null allele, HLA-G*0105N. Previous studies have shown that HLA-G*0105N does not encode the complete HLA-G1 or HLA-G5 isoforms but encodes a functional HLA-G protein with the ability to in-hibit NK cell cytolysis. Thus, although the biological functions of HLA-G1 and HLA-G5 proteins are abrogated, other isoforms such as HLA-G2 can replace th...