The molecular structure of a new group of AZT derivatives, namely, AZT 5′-aminocarbonylphosphonates anti-HIV drugs is presented by means of quantum chemical DFT/B3LYP calculations with full relaxation of all the geometrical parameters. They are reverse transcriptase inhibitors and derivatives of the nikavir nucleoside analogue used actually in clinic, but they are less toxic an offer an advanta...

1. Cyclohexylpuromycin, an anlogue of puromycin in which a cyclohexane ring replaces the aromatic benzene ring of the L-phenylalanyl moeity of the nucleoside., has been synthesized and examined for its ability to release N-acetylphenylalanine from tRNA attached to rat liver ribosomes. 2.dl-Cyclohexylpuromycin was active in reacting with N-[3H]acetylphenylalanyl-tRNA on rat liver ribosomes to fo...

BACKGROUND Entecavir is a potent nucleoside analogue for treating chronic hepatitis B (CHB). Quantitative hepatitis B surface antigen (qHBsAg) levels are predictive of response to interferon-α in CHB treatment; however, the clinical utility of qHBsAg in nucleoside/nucleotide analogue-based CHB therapy is not fully characterized. This study assessed changes in qHBsAg in patients treated with ent...

Treatment related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) are well known complications after chemotherapy for various hematologic and non-hematologic malignancies. Alkylating agents and Topoisomerase inhibitors are most widely studied in this regard. There is growing concern about occurrence of t-MDS, t-MDS/AML and t-AML in patients of CLL treated with nucleoside ana...

After zidovudine (ZDV), a 3′-azido analogue of thymidine, was found to be an effective antiretroviral drug against HIV [1,2], other nucleoside analogues inhibiting reverse transcriptase (RT) soon followed: didanosine (ddI), zalcitabine (ddC), lamivudine (3TC), stavudine (D4T), and recently abacavir (1592U89) [3–7]. These drugs have demonstrated efficacy in reduction of morbidity and mortality, ...

Submit Manuscript | http://medcraveonline.com Abbreviations: PLHIV: People Living With HIV; HAART: Highly Active Antiretroviral Therapy; ART: Antiretroviral Therapy; ARV: Antiretroviral Drug; NNRTI: Non-Nucleoside ReverseTranscriptase Inhibitor; NRTI: Nucleoside Reverse-Transcriptase Inhibitor; PI: Protease Inhibitor; HIVDR: HIV Drug Resistance; PDR: Pretreatment HIV Drug Resistance; ADR: Acqui...