نتایج جستجو برای: nsaids

تعداد نتایج: 6221  

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003
Yunqian Pan Jin-San Zhang Mozammel H Gazi Charles Y F Young

Nonsteroidal anti-inflammatory drugs (NSAIDs) play potential roles in cancer chemoprevention. In this study, we investigated the effects of NSAIDs on androgen receptor (AR)-mediated functions in prostate cancer cells. We found that two cyclooxygenase 2-specific NSAIDs, celecoxib and nimesulide, dramatically reduced the expression of androgen-inducible genes, such as prostate-specific antigen, h...

2002
Maxime Dougados

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) effects in Ankylosing Spon-dylitis (AS) are only suspensive but because of their rapid efficacy on inflam-matory symptoms they are the first-line treatment in AS. Short term efficacy of NSAIDs in AS is observed for most patients but the correlation of NSAID intake with the long term prognosis and its potential influence on the structural progression...

Journal: :Drugs 2000
C A Heyneman C Lawless-Liday G C Wall

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs worldwide and are responsible for approximately one-quarter of all adverse drug reaction reports. NSAIDs are widely prescribed for patients with rheumatic disease--a population at increased risk for serious gastrointestinal (GI) complications. Topical administration of NSAIDs offers the advantage of local...

Journal: :Arquivos brasileiros de cardiologia 2010
Luciano Passamani Diogo David Saitovitch Michelle Biehl Laura Fuchs Bahlis Maria Claudia Guterres Cinthia Fonseca O'Keeffe Gustavo Franco Carvalhal Paulo Ricardo Avancini Caramori

BACKGROUND The association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) and acute or chronic renal failure is well documented, but evidence of such association between NSAIDs and Contrast-Induced Nephropathies (CIN) is not found in the indexed literature. OBJECTIVE To evaluate the possible association between NSAIDs and CIN. METHODS In a cohort study, through clinical in...

Journal: :Arthritis Research & Therapy 2006
Gurkirpal Singh Olivia Wu Peter Langhorne Rajan Madhok

The use of cyclo-oxygenase 2 selective nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with increased risk of acute myocardial infarction (AMI). The association between the risks of AMI with nonselective NSAIDs is less clear. We reviewed the published evidence and assessed the risk of AMI with nonselective NSAIDs. We performed a meta-analysis of all studies containing data from popu...

Journal: :The Journal of pharmacology and experimental therapeutics 2002
Khosrow Kashfi Yassir Rayyan Leon L Qiao Jennie L Williams Jie Chen Piero Del Soldato Frank Traganos Basil Rigas Yassir Ryann

The novel nitric oxide (NO)-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs), which are safer than their NSAID counterparts, inhibit the growth of colon cancer cells with far greater potency than traditional NSAIDs. We examined whether NO-NSAIDs inhibit the growth of cancer cells arising from other human tissues. Human pancreatic, colon, prostate, lung, and tongue cancer cell lines wer...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Timothy D Warner Jane A Mitchell

N onsteroidal antiinflammatory drugs (NSAIDs) and prostanoids continue to be fascinating research targets. Humans have been using NSAIDs in one form or another, from folk remedies through to the products of modern pharmaceutical research, for thousands of years. However, we still have not characterized all of the systems through which these drugs produce their beneficial and harmful effects (1,...

2014
Casilda M Balmaceda

Goals for the management of osteoarthritis (OA) emphasize pain relief, reduction of inflammation, and improvement in functioning. Among pharmacological pain management interventions, nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently recommended as the most effective treatment option for OA. However, the use of traditional oral NSAIDs is associated with risk of serious adverse events ...

2017
Vera M. Kroesen Matthias I. Gröschel Neil Martinson Alimuddin Zumla Markus Maeurer Tjip S. van der Werf Cristina Vilaplana

Lengthy, antimicrobial therapy targeting the pathogen is the mainstay of conventional tuberculosis treatment, complicated by emerging drug resistances. Host-directed therapies, including non-steroidal anti-inflammatory drugs (NSAIDs), in contrast, target host factors to mitigate disease severity. In the present Systematic Review, we investigate whether NSAIDs display any effects as therapy of T...

Journal: :Journal of clinical pathology 1994
A S Taha S Dahill I Nakshabendi F D Lee R D Sturrock R I Russell

AIMS To study the oesophageal histological changes in long term users of non-steroidal anti-inflammatory drugs (NSAIDs) compared with patients not receiving these drugs. METHODS Ninety eight patients were studied, 53 of whom had taken NSAIDs for three years; 45 had not. Oesophageal biopsy specimens were taken from healthy-looking mucosa in the lower third of oesophagus. The papillary length, ...

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