نتایج جستجو برای: nsaid
تعداد نتایج: 3734 فیلتر نتایج به سال:
Results: The median age of the patients was 62 and the male to female ratio 1.4: 1. In 64.2% of the cases a gastroduodenal ulcer was found. There was a history of NSAID use in 60.6% of patients and NSAID administration was associated significantly with antral erosions (81.7%). Operation and mortality rate were 3.6% and 2.7% respectively. Taking into account the local drug circulation, salicylat...
The ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effec...
Acetabular destruction can significantly increase the difficulty of performing hip replacement and is, therefore, a much more important consideration than femoral head necrosis. In this study acetabular migration was used as a measure of acetabular destruction. Fifty-eight patients undergoing total hip replacement at the Princess Elizabeth Orthopaedic Hospital for primary osteoarthritis were st...
The mechanisms by which nonsteroidal anti-inflammatory drugs (NSAIDs) induce apoptosis in colorectal cancer cells are undergoing intensive investigation. We found previously that NSAIDs induce apoptosis in these cells by restoring 15-lipoxygenase-1 (15-LOX-1) expression. The present study examined the NSAID mechanism for up-regulating 15-LOX-1 in two colorectal cancer cell lines (RKO and DLD-1)...
Correspondence to: Kam-Chuen Lai Abstract: Adverse reactions to non-steroidal anti-inflammatory drugs (NSAIDs) are common. Upper gastrointestinal complications including ulcer bleeding, perforation and obstruction are the most serious complications that can result in substantial morbidity and mortality. Many NSAID-using patients present with complications without any preceding symptoms. Risk fa...
Ageing has been suggested to cause changes in the intestinal microbial community. In the present study, the microbiota of a previously well-defined group of elderly subjects aged between 70 and 85 years, both non-steroidal anti-inflammatory drugs (NSAID) users (n 9) and non-users (n 9), were further compared with young adults (n 14) with a mean age of 28 years, by two DNA-based techniques: perc...
BACKGROUND The single-blind, placebo controlled oral challenge (SBPCOC) is the definitive way to diagnosis nonsteroidal anti-inflammatory drug (NSAID)-induced reactions. OBJECTIVE To evaluate 223 NSAID-sensitive patients by means of SBPCOC, and to describe the main clinical patterns found. METHODS A prospective study was carried out, including 2 patient groups with case histories consistent...
Non-steroidal anti-inflammatory drug (NSAID) toxicity in the upper gastrointestinal tract is the most common serious drug-induced toxicity reported to drug regulatory authorities. In the last two decades, the rediscovery of H. pylori, development of potent ulcer-healing drugs and specific Cox-II inhibitors have opened new horizons in the management of NSAID toxicity. A Working Party composed of...
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