Osteocrin (Ostn) is a recently discovered secreted protein produced by cells of the osteoblast lineage that shows a well conserved homology with members of the natriuretic peptide (NP) family. We hypothesized that Ostn could interact with the NP receptors, thereby modulating NP actions on the skeleton. Ostn binds specifically and saturably to the NP peptide receptor-C (NPR-C) receptor with a Kd...

Nation building is a task in which the process of national integration and unifying nationalities various cultures languages, undertaken to achieve homogeneous culture. The article explains whereby people transfer their commitment loyalty from smaller tribe, village petty principalities larger central political system,

Elesgaray R, Caniffi C, Savignano L, Romero M, Mac Laughlin M, Arranz C, Costa MA. Renal actions of atrial natriuretic peptide in spontaneously hypertensive rats: the role of nitric oxide as a key mediator. Am J Physiol Renal Physiol 302: F1385–F1394, 2012. First published February 29, 2012; doi:10.1152/ajprenal.00624.2011.—Atrial natriuretic peptide (ANP) is an important regulator of blood pre...

PURPOSE To demonstrate the presence of natriuretic peptide receptors (NPRs) in primary human corneal epithelial cells (p-CEPI), SV40-immortalized CEPI cells (CEPI-17-CL4) and in human corneal epithelium, and to define the pharmacology of natriuretic peptide (NP)-induced cGMP accumulation. METHODS NPR presence was shown by RT-PCR, western blot analysis, and indirect immunofluoresence. cGMP acc...

C-type natriuretic peptide (CNP) and its cognate guanylyl cyclase receptor, the natriuretic peptide receptor B (NPR-B) together constitute a regulatory system that controls cell function via the generation of intracellular cyclic GMP. In this report we have examined the role of cAMP signaling in the regulation of CNP and NPR-B activity in the FRTL-5 rat thyroid follicular cell line. As had been...

ion, and mobile platforms offer relatively less computing power. So, a convergence of these areas can help deal with producing complex renderings on resource-constrained mobile platforms. This tutorial presents the state of NPR techniques for mobile devices, to motivate the development of efficient mobile NPR apps.

Magnocellular neurosecretory cells (MNCs), of the paraventricular and supraoptic nuclei of the hypothalamus, secrete the hormones vasopressin and oxytocin. As a result, they have an essential role in fundamental physiological responses including regulation of blood volume and fluid homeostasis. C-type natriuretic peptide (CNP) is present at high levels in the hypothalamus. Although CNP is known...

Cardiovascular and immune system abnormalities have been reported in females with estrogen deficiency. To control these disorders in post-menopausal women, hormone replacement therapy (HRT) has been used. Tibolone has been used as a HRT, but the effects of tibolone on the natriuretic peptide system have not been determined. We investigated the effects of tibolone on the natriuretic peptide syst...