One of the key research agenda of the field of aging is investigation of presymptomatic Alzheimer's disease (AD). Furthermore, abnormalities in brain glucose metabolism (as measured by FDG-PET) have been reported among cognitively normal elderly persons. However, little is known about the association of FDG-PET abnormalities with neuropsychiatric symptoms (NPS) in a population-based setting. Th...

We tested the efficacy and tolerability of one-year treatment with memantine (10 mg bid) in behavioral variant frontotemporal dementia (bvFTD). BvFTD patients aged 45 to 75 years, with a Mini-Mental Status Examination (MMSE) score ≥19, were enrolled in a national, randomized, double-blind, placebo-controlled (DBPC), Phase II trial. The primary endpoint was the CIBIC-Plus (Clinician's Interview-...

Luria-Nebraska Neuro-psychological Battery, is now an established tool to assess brain damage in recent years. This test battery has been reported to be very useful to find out functional organization of the brain. The biological basis of psychiatry is also now well explained. The present study is directed towards the neuro-psychological functioning of schizophrenic disorder, and the findings a...

OBJECTIVE The objective of this study was to conduct exploratory analyses of data pertaining to the efficacy of donepezil treatment of patients with severe behavioral disturbances. Preliminary studies suggest that cholinesterase inhibitors, including donepezil, may reduce behavioral disturbances in patients with Alzheimer disease (AD). Most patients included in clinical trials have had low leve...

In addition to cognitive impairment, behavioral and psychological symptoms of dementia (BPSD) are another important aspect of most dementia patients. This study was designed for a new simple assessment of BPSD. We first employed a clinical survey for the local community with sending an inquiry letter to all members (n=129) of dementia caregiver society, and then attempted to create a new BPSD s...

OBJECTIVES To assess the effects of active music therapy (MT) and individualized listening to music (LtM) on behavioral and psychological symptoms of dementia (BPSDs) in persons with dementia (PWDs). DESIGN Randomized controlled trial. SETTING Nine Italian institutions. PARTICIPANTS Persons with moderate to severe dementia and BPSDs (N = 120) were randomized to one of three treatments. ...

INTRODUCTION This study examined the level of agreement between caregiver and Parkinson's disease (PD) patient reports of neuropsychiatric problems. METHOD Forty-three patients and 43 informants who knew the patient well (caregivers) participated in the study. Caregivers rated patients' behaviour, as well as their own stress, using the Neuropsychiatric Inventory (NPI). Information from patien...

Submit Manuscript | http://medcraveonline.com J Psychol Clin Psychiatry 2015, 3(4): 00144 death [1]. There have been several recent publications consistent with premature deaths associated with discontinuation of opiates independent of withdrawal induced adverse events [2-4]. There is also compelling neuro imaging evidence of brain atrophy associated with chronic pain and depression [5-6]. A nu...

At the outset, I would like to express my deep gratitude to the distinguished membership of the Indian Psychiatric Society for giving me an opportunity to deliver Dr D L N Murthy Rao Oration. Dr Murthy Rao was one of the foremost psychiatrist in our country and as a Professor and Director of the National Institute of Mental Health and Neuro-Sciences, Bangalore, he not only trained many eminent ...

It is commonly argued that weak negative polarity items (NPIs) (e.g., any) can occur in any (Strawson) downward-entailing environment. This generalization, however, is challenged byWagner’s (2006) observations with the NPI-licenser only: although an only-clause is (Strawson) downward-entailing in its unfocused part, NPIs are not necessarily licensed there. In particular, DPonly does not license...