OBJECTIVE Cloning of the ileal apical sodium-dependent bile acid transporter (ASBT) has identified a new pharmacological target for the modulation of plasma lipoproteins. The objective of this study was to determine whether a novel, specific, minimally absorbed ASBT inhibitor (SC-435) decreases LDL cholesterol through the alteration of plasma apoB kinetics. METHODS AND RESULTS Miniature pigs ...

HER-2/neu is a self-antigen expressed by tumors and nonmalignant epithelial tissues. The possibility of self-tolerance to HER-2/neu-derived epitopes has raised questions concerning their utility in antitumor immunotherapy. Altered HER-2/neu peptide ligands capable of eliciting enhanced immunity to tumor-associated HER-2/neu epitopes may circumvent this problem. The human CTL peptide HER-2/neu (...

Fluorescent-labeled substrates are provided for fluorescence 21 Appl. No.: 566,390 polarization assays of enzymes. These Substrates are pro 1-1. teins labeled with derivatives of BODIPY(R), 44-difluoro 22 Filed: Dec. 1, 1995 5,7-dimethyl-4-bora-3a,4a-diaza-S-indacene. The 51) Int. Cl. ........................ G01N 33/573; G01N 33/53; BODIPYOR) fluorescent tag of the present invention is pH C12O...

Discovery of the ileal apical sodium-dependent bile acid transporter (ASBT) permitted development of specific inhibitors of bile acid reabsorption, potentially a new class of cholesterol-lowering agents. In the present study, we tested the hypothesis that combining the novel ASBT inhibitor, SC-435, with the HMG-CoA reductase inhibitor, atorvastatin, would potentiate reductions in LDL cholestero...

INTRODUCTION.................................................................................. 431 PROBLEMS IN THE ETIOLOGICAL STUDY OF VIRAL RESPIRATORY ILLNESS IN INFANTS AND CHILDREN 431 CLINICALLY INDISTINGUISHABLE RESPIRATORY ILLNESSES.433 Rhinitis...................................................................................... 433 Tonsillitis or Pharyngitis 43 Exanthematous Disease 4...

(51) Int. Cl. B03C1102 (2006.01) C12M 1/00 (2006.01) (52) U.S. Cl. USPC ................... 210/222; 252/62.51 R; 422/68.1; 422/502; 422/504; 422/527; 435/287.2; 435/308.1; 436/526; 436/806 (58) Field of Classification Search USPC ........... 210/222; 252/62.51 R; 422/68.1, 502, 422/504, 527; 435/287.2, 308.1; 436/526, 436/806 See application file for complete search history. (1o) Patent No.: U...

In support of the recent article by Chambers (1), we wish to share our data on the origin of the MDA-MB-435 and M14 cell lines. Chambers claims that it is most plausible that both cell lines represent MDA-MB-435 based on two X chromosomes in the MDAMB-435 karyotype, whereas M14 had been derived from a man (1). However, karyotyping does not discriminate between paternal and maternal alleles and ...

Our study was undertaken in order to determine the effects of preliminary hydrothermal depolymerization and enzymatic hydrolysis of macroalgae biomass originating from the Vistula Lagoon on yield of the methane fermentation process in terms of quantity and quality of produced biogas. The process of enzymatic hydrolysis was conducted with a mixture of enzymes: Cellulast 1.5 L, Novozym 188, and H...