A novel magnetite nanoparticle-based heterogeneous acidic catalyst [Fe3O4@SiO2@Am-PPC-SO3H] [HSO4] was successfully prepared and characterized by SEM, EDX, TGA, VSM and FT-IR techniques. The magnetically retrievable and sustainable catalyst was investigated in the reaction of aldehyde and o-aminophenol for the synthesis of benzoxazoles. The...

A novel series of indole and quinoline tricarboxamides were synthesized using simple and efficient one-pot pseudo-five-component reactions of 2-formylindole or 2-chloro-3-formyl quinolines, isocyanides, amines, and Meldrum’s acid as a CH-acid in CH2Cl2 at room temperature. This conversion has been achieved via the construction of new bonds including two C-C bonds, two ...

In this paper we discuss an approach to user evaluation for novel ICT products developed for a rural subSaharan context. We report on an evaluation study of the DUCE method using UK based and Kenyan based users.

Introduction Mitochondria1 monoamine oxidase (MAO; EC 1.4.3.4) catalyses the oxidative deamination of a variety of primary, secondary and tertiary amines. Until very recently most of the attention concerning MA0 activity was focused on the reaction of this enzyme to deaminate neurotransmitter substances, including adrenaline, noradrenaline, serotonin and dopamine. The ability of MA0 to regulate...

Natural products have been a prolific source of antibacterial and anticancer drugs for decades. One of the major challenges in natural product discovery is that the vast majority of natural product biosynthetic gene clusters (BGCs) have not been characterized, partially due to the fact that they are either transcriptionally silent or expressed at very low levels under standard laboratory condit...

BACKGROUND Nature has been a source of medicinal products for millennia, with many useful drugs developed from plant sources. Following discovery of the penicillins, drug discovery from microbial sources occurred and diving techniques in the 1970s opened the seas. Combinatorial chemistry (late 1980s), shifted the focus of drug discovery efforts from Nature to the laboratory bench. SCOPE OF RE...

Historically, nature has provided the source for the majority of the drugs in use today. This owes in large part to their structural complexity and clinical specificity. However, only a small percentage of known microbial secondary metabolites have been tested as natural-product drugs. Natural-product programs need to become more efficient, starting with the collection of environmental samples,...

Novel screens have been developed for the detection of antitubercular activity among natural product extracts and these were compared with existing methodologies. Using bioassaydirected methods these screens have been employed to isolate novel antitubercular natural products from higher plant extracts and their structures have been determined. In particularly promising cases, exemplified by try...