BACKGROUND Prolonged metabolic abnormalities have been demonstrated previously in postischemic myocardium, including relative increases in glucose uptake and abnormal fatty acid kinetics. However, quantitative metabolic information is limited, and the time course of changes in MVO2 in postischemic myocardium is unknown. To address these issues, chronically instrumented dogs were studied seriall...

BACKGROUND AND PURPOSE Deep white matter may be the location of an internal arterial border zone. The purpose of this study was to determine whether the deep white matter was subject to a greater degree of ischemia than was the cortex among patients with chronic carotid occlusion. METHODS Thirty-six patients with carotid occlusion and structurally normal deep white matter were studied with po...

The effect of acute cerebral occlusion on the distribution of cerebral perivascular nerves containing catecholamine, neuropeptide Y, and vasoactive intestinal peptide was studied in the three commonly used rat models of cerebral ischemia: Unilateral permanent middle cerebral artery (MCA) occlusion induced with an intraluminal thread technique; unilateral MCA occlusion produced by extraluminal e...

BACKGROUND AND PURPOSE Stroke severity in cases of hyperacute carotid ischemic stroke may be related to site of arterial occlusion. We evaluated the relationships between National Institutes of Health Stroke Scale (NIHSS) scores and findings on intra-arterial digital subtraction angiograms (IA-DSA) of patients with ischemic stroke within 6 hr of stroke onset. METHODS A total of 43 consecutive...

The effect of change of posture on the level of the intraocular pressure was studied in 22 patients who had suffered 'occlusion' of a central retinal vein, 14 patients with occlusion of a tributary of the central vein, and 23 normal subjects. The results showed a significant difference in behaviour between subjects in the control group and both groups of patients with retinal vein occlusions. I...