Cancer is a major cause of death worldwide, as exemplified by millions cancer diagnoses every year. The use chemotherapy in treating has many disadvantages which include recurrence cancer, associated with drug resistance, and severe side effects that are harmful to the patients. A better source anticancer drugs can come from nature. Strobilanthes crispus (S. crispus) herbal medicinal plant indi...

Proanthocyanidins (PACs) are polymers of flavan-3-ols abundant in many vegetable foods and beverages widely consumed in the human diet. There is increasing evidence supporting the beneficial impact of dietary PACs in the prevention and nutritional management of non-communicable chronic diseases. It is considered that PACs with a degree of polymerization >3 remain unabsorbed in the gastrointesti...

The abietane-type diterpenoid (+)-ferruginol, a bioactive compound isolated from New Zealand's Miro tree (Podocarpus ferruginea), displays relevant pharmacological properties, including antimicrobial, cardioprotective, anti-oxidative, anti-plasmodial, leishmanicidal, anti-ulcerogenic, anti-inflammatory and anticancer. Herein, we demonstrate that ferruginol (1) and some phthalimide containing an...

A series of chalcone-based diarylpyrazoles containing a phenylsulphone or carbonitrile moiety was synthesized. Thus, 3-acetylpyrazoles 6a-c and 10a-c were used as useful substrates in facile synthesis of functional pyrazoles 7a-f and 11a-f, respectively. The anti-inflammatory activity and ulcerogenic effect were evaluated and some of the obtained products possessed a significant anti-inflammato...

Coombs and Gell1) classified allergic phenomena into four types, of which three (types I, II and III) are immediate-type, and one (type IV) is delayed-type. The former reactions are caused by humoral antibodies, while the latter is caused by a cellular antibody. We have already reported that the carboxamidemethylated L chain2) and the carboxamidemethylated H and L chains') show anti-ulcerogenic...

Atherosclerosis being considered as an inflammatory disorder, the present study was undertaken to investigate the effectiveness of anti-inflammatory drugs (ibuprofen, aspirin, and celecoxib) in hypercholesterolemia. Ibuprofen is a cyclooxygenase (COX-1 and COX-2) inhibitor known to reduce the production of prostaglandins that play prominent role in inflammation. Beside the anti-inflammatory eff...