Drug-drug interactions (DDIs) are defined as clinically meaningful alterations in the exposure and response to a drug (called object drug) that has occurred as a result of the co-administration of another drug (called precipitant drug). According a 2011 study, drug-drug interactions (DDIs) are responsible for roughly 220,000 hospital admissions per year (Percha and Altman 2013). However, this n...

PURPOSE Curcumin is a hydrophobic polyphenol isolated from dried rhizome of turmeric. Clinical usefulness of curcumin in the treatment of cancer is limited due to poor aqueous solubility, hydrolytic degradation, metabolism, and poor oral bioavailability. To overcome these limitations, we proposed to fabricate curcumin-piperine, curcumin-quercetin and curcumin-silibinin loaded polymeric nanoform...

In standard drug self-administration settings, animals have no choice than drug use. As a result, serious doubt exists about the interpretation of drug use in experimental animals. Is it symptomatic of an underlying addiction state or merely an expectable response to lack of choice? This incertitude in turn casts a shadow over many behavioral and neurobiological changes that have been well docu...

Here, we demonstrate detection by mass spectrometry of an intact protein–drug complex directly from liver tissue rats that had been orally dosed with the drug. The comprised fatty acid binding protein 1, FABP1, non-covalently bound to small molecule therapeutic bezafibrate. Moreover, spatial mapping [FABP1+bezafibrate] across a thin section targeted imaging. This work is first demonstration in ...