Neurocristic cutaneous hamartoma of the scalp, a rare entity, may be either congenital or acquired. The former must be distinguished from other forms of congenital nodular and plaque-like lesions such as giant congenital nevi, common and cellular blue nevi, and melanoma. We describe the clinicopathologic features of an example occurring in a 2-month-old girl presenting with a large parietooccip...

Objective: To review the records of cases of vulvar melanoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between 1986 and 2009 recognising the high incidence of cutaneous melanoma in Queensland. Methods: Vulvar melanoma case data from QCGC were reviewed and analysed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. Results: Of the 46 cas...

Growing evidence suggests that the cancer stem cell phenotype in melanoma is dynamically regulated. Therefore, effective therapies have to target simultaneously bulk tumor cells and melanoma stem-like cells. The aim of the present study was to investigate the effects of parthenolide on heterogeneous cancer cell populations from anchorage-independent melanospheres. Cells derived from nodular mel...

Primary cutaneous melanomas are usually divided into three separate clinicopathologic groups: lentigo maligna melanoma (LMM), superficial spreading melanoma. (SSM), and nodular melanoma (NM). Acral lentiginous melanoma has been described as the fourth distinct subtype to denote those melanomas that arise on volar and subungual skin. This entity is said to have a radial growth phase histological...

Abstract Background Nodular (NM) and superficial spreading melanoma (SSM) show different disease trajectories, with more rapid development in NM fewer opportunities for early detection often resulting worse outcomes. Our study described the patient-identified signs of thin via comparisons to (≤ 2 mm) SSM thick (> NM. Methods We conducted semi-structured interviews patients analyzed data usin...

This article describes the case of a 62-year-old patient who developed an erosive nodular mass on the nail apparatus after receiving a trauma during a hunting incident. The lesion was initially diagnosed as an amelanotic melanoma of the nail apparatus, illustrating the fact that this type of lesion is often misdiagnosed – up to 85% of the time if the physician lacks dermatological expertise –an...

OBJECTIVE To compare the prognosis of patients with scalp or neck (scalp/neck) melanomas with that of patients with melanomas at other sites in a large, population-based national data set controlling for known prognostic factors. DESIGN Retrospective cohort study using US cancer registries that constitute the Surveillance, Epidemiology, and End Results 13 Registries (SEER-13) database. PATI...

The term “nevoid malignant melanoma” (nevoid MM) is used here to describe rare nodular malignant melanomas that may escape detection in routine histological sections due to the lack of a prominent intraepidermal component, sharp lateral circumscription and evidence of partial maturation with descent in the dermis (1). Nevoid MM mimic ordinary compound or intradermal melanocytic nevi when the me...

We report a case of metastatic malignant melanoma resembling a malignant peripheral sheath tumor, which posed a significant diagnostic challenge. The patient is a 76-year-old male, who presented in the emergency room with bilateral chest pain exacerbated by inspiration. The pain was present for 3 week and was not exacerbated by physical exercise. The diagnostic workup revealed bilateral parench...

El melanoma es el cáncer de piel con mayor mortalidad a nivel mundial. Se han descrito 4 subtipos principales en cutáneo; extensión superficial, nodular, lentigo maligno y lentiginoso acral. Existen diferencias raciales la distribución frecuencia éstos subtipos. En caucásicos, riesgo para melanomas expuesta radiación UV, ya sea forma crónica o intermitente. contraste, asiáticos, afroaméricanos ...