Cistus ladanifer L. is a medicinal shrub traditionally used against several diseases. The present study was performed for trying to enrich the potentialities of this plant by evaluating possible analgaesic effect aqueous extract Cistus. (AECL) and oral formulation prepared from AECL. tested using acetic acid induces writhing formalin models. results showed that both herbal syrup induced signifi...

The analgesic mechanism of morphine on the spinal nociceptive transmission was compared in rabbits with the intact and cold-blocked states of the spinal cord. The degree of the suppressive effect of morphine (2 mg/kg) on the bradykinin-induced activity was significantly greater in the intact than in the cold-blocked states. Morphine (4 mg/kg) suppressed the nociceptive responses to similar leve...

The detection of harmful stimuli - nociception - has been suggested to rely on evolutionarily conserved neuronal mechanisms. A recent study has shown how the activity of nociceptive neurons in Drosophila larvae triggers a defense mechanism against a parasitoid wasp.

Background; Coccygodynia is a musculoskeletal disease that affects quality of life. The main complaint coccygodynia nociceptive and/or neuropathic pain. Vitamin D deficiency has been associated with the development pain in various diseases. 
 Aims; In this study we aimed investigate types (nociceptive, neuropathic, mixed) and relationship between level patients coccygodynia. Study design; ...

Inflammation, trauma, or nerve injury may cause enduring hyperalgesia, an enhanced sensitivity to painful stimuli. Neurons in lamina I of the spinal dorsal horn that express the neurokinin 1 receptor for substance P mediate this abnormal pain sensitivity by an unknown cellular mechanism. We report that in these, but not in other nociceptive lamina I cells, neurokinin 1 receptor-activated signal...

We studied the effect of cholecystokinin (CCK-8) and yohimbine-alpha-2-adrenoreceptor antagonist administered locally into lateral reticular formation (LRF) on the bioelectrical response to the pain stimulation. The experiments were carried out on 8 conscious rabbits with bilaterally implanted electrodes into: motor-sensory cortex, ventro-postero-lateral thalamic nuclei, hippocampus and LRF. No...

Venoms are produced by a wide variety of species including spiders, scorpions, reptiles, cnidarians, and fish for the purpose of harming or incapacitating predators or prey. While some venoms are of relatively simple composition, many contain hundreds to thousands of individual components with distinct pharmacological activity. Pain-inducing or "algesic" venom compounds have proven invaluable t...

In anesthetized rats, opioid analgesia is accompanied by a specific pattern of tonic activity in two neuronal populations within the medullary raphe magnus (RM): opioids silence pain-facilitatory ON cells and produce sustained discharge in pain-inhibitory OFF cells. These tonic activity patterns, hypothesized to generate a tonic analgesic state, have not been observed in recordings made without...