for the first time in English an authentic treatise on this subject. Such a work could only be the product of a master of his subject and Palmer Findley has long been recognized as a leader in American Obstetrics. Bearing in mind that "History is the essence of innumerable biographies" the author has used this approach to the subject with great effectiveness. The great personalities of obstetri...

The authors show that the Mesoproterozoic (1.6-1.0 bn year before present) was no “boring billion” but a “bustling billion” - not only with Stromatolites and their apex in the Calymmian and Ectasian but also with the presence of multicellular organisms. To make it visible a graphical reconstruction was created. For a long time, it was assumed that there existed no noteworthy biosphere on Earth ...

Let P be a set of n points in d-dimensional Euclidean space, where each of the points has integer coordinates from the range [−∆, ∆], for some ∆ > 1. Let ε > 0 be a given parameter. We show that there is subset Q of P , whose size is polynomial in (log ∆/ε), such that for any k slabs that cover Q, their ε-expansion covers P. In this result, k and d are assumed to be constants. The set Q can als...

e s asectomy is the safest and most dependable method of permanent contraception available o men today. More than 500,000 vasectomies are erformed in the United States and more than 5,000 in Canada each year. Of American married ouples, 7% to 10% choose vasectomy as their form f birth control. This has made vasectomy the most ommon urologic procedure in North America.1–3 Although vasectomy is a...

No crystal structure? No problem I t’s hard for crystallographers to determine the structures of all the macromolecular assemblies that cell biologists want to get a close look at. But researchers can piece together precise molecular structures by considering other readily available data, Fernandez-Martinez et al. suggest. Their new work builds on their previous fi ndings that highlighted the v...

In Learning with Label Proportions (LLP), the objective is to learn a supervised classifier when, instead of labels, only label proportions for bags of observations are known. This setting has broad practical relevance, in particular for privacy preserving data processing. We first show that the mean operator, a statistic which aggregates all labels, is minimally sufficient for the minimization...

A novel mechanism has been defined for controlling per-oxisome proliferator-activated receptors γ (PPARγ) activity in response to thiazolidinedione (TZD) ligands, in which deacetylation of PPARγ by SirT1 remodels the transcriptional complex. This change favors expression of genes associated with increased energy use and insulin sensitization in white adipose tissue (WAT), and is required for a ...