نتایج جستجو برای: nitroimidazole

تعداد نتایج: 662  

2016
A.M. Jarrad A. Debnath Y. Miyamoto K.A. Hansford R. Pelingon M.S. Butler T. Bains T. Karoli M.A.T. Blaskovich L. Eckmann M.A. Cooper

Diarrhoeal diseases caused by the intestinal parasites Giardia lamblia and Entamoeba histolytica constitute a major global health burden. Nitroimidazoles are first-line drugs for the treatment of giardiasis and amebiasis, with metronidazole 1 being the most commonly used drug worldwide. However, treatment failures in giardiasis occur in up to 20% of cases and development of resistance to metron...

Journal: :Journal of medicinal chemistry 2008
Jian-Xin Duan Hailong Jiao Jacob Kaizerman Timothy Stanton James W Evans Leslie Lan Gustavo Lorente Monica Banica Don Jung Jinwei Wang Huaiyu Ma Xiaoming Li Zhijian Yang Robert M Hoffman W Steve Ammons Charles P Hart Mark Matteucci

A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug, ifosfamide. The hypoxia-selective cytotoxicity of several of the compounds was improved over previously reported racemic mixtures of chiral bioreductive phosphoramidate prodrugs. Prodrugs activated by 2-nitroimidazole reduction demonstrated up to 400-fold enhanced cytotoxi...

Journal: :journal of sciences islamic republic of iran 0

reaction of substituted-aniline (8) with ethyl (l-methyl-5-nitroimidazole-2- carbonyl) acetate (9) gave 4-hydroxy-2-(l-methyl-5-nitro-2-imidazolyl)- substituted-quinolines (lo), which were converted to compound 11 with phosphorus oxychloride. substituted-2-(l-methyl-5-nitro-2-imidazo1yl)-4.- methyl-(or phenyl-) quinolines (14) were prepared through the reaction of 2- acetyl-5-nitro-1-methyl-imi...

Journal: :Infectious Diseases in Obstetrics and Gynecology 1998
A M Wain

KEY WORDS bacterial vaginosis; metronidazole etronidazole vaginal gel 0.75% (MetroGel-Vaginal(R), 3M Pharmaceuticals, St. Paul, MN) is the intravaginal form of the antibacterial, anti-protozoal agent metronidazole. MetroGel-Vaginal is indicated for the treatment of bacterial vaginosis (BV) and has been shown to be as effective as the oral form of metronidazole for this condition. Recently , a s...

Hossein Hooshyar, Mahdi Delavari, Mohsen Arbabi, Zohreh Fakhrieh Kashan,

Trichomonas vaginalis is a flagellated parasite affecting about 276 million people annually worldwide. Tricomoniasis is associated with different complications in pregnant women and infants. 5'-nitroimidazole derivatives (metronidazole, ornidazole, and tinidazole) are FDA approved drugs recommended for trichomoniasis treatment. Treatment with metronidazole 5'-nitroimidazole derivatives is assoc...

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