The electrochemical properties of twenty 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives with varying degrees of cytotoxic activity were investigated in dimethylformamide (DMF) using cyclic voltammetry and first derivative cyclic voltammetry. With one exception, the first reduction of these compounds was found to be reversible or quasireversible and is attributed to reduction of th...

g -aminobutiric acid (gaba), the major inhibitory neurotransmitter in the central nervous system has two major receptor subtypes (gabaa and gabab). gabab receptors are activated by the antispastic and muscle relaxant agent, baclofen, which is a lipophilic derivative of gaba. since 1962 several strategies have been reported for the synthesis of baclofen.in this study an approach has been made to...

Subsequent reduction and dearomatizing cyclization reactions open up an entry into the synthesis of novel N-fused polycyclic indolines. The as key step sequence proceeds well with Cu(OTf)2 or TfOH catalyst. At elevated temperature nitro-substituted precursors iron under acidic conditions affords a broad variety indolines directly in two-step cascade reaction good to excellent yields. Using deve...

The reduction chemistry of the new anti-tuberculosis drug PA-824, together with a more water-soluble analogue, have been investigated using pulse and steady-state radiolysis in aqueous solution. Stepwise reduction of these nitroimidazo-dihydrooxazine compounds through electron transfer from the CO(2) (-) species revealed that, unlike related nitroimidazoles, 2-electron addition resulted in the ...

in chronic myelogenous leukemia (cml), the mature granulocytes originate from a stem cell line harboring an abnormal chromosome, therefore it is possible that metabolic-functional abnormalities occur in the morphologically mature cells. in the present study, the phagocytic activity including intracellular killing, nitro blue tetrazolium (nbt) reduction, and phagocytosis were studied in 37 cml p...

The metabolism of nitro compounds in plants has not been extensively investigated. Only two such compounds appear to have been reported as occurring naturally in plants. Chloromycetin contains an aromatic nitro group, and occurs in the culture medium of Streptomyces. Certain bacteria (1) and, more recently, a bacterial cell-free enzyme (2) have been shown to bring about the reduction of the nit...