نتایج جستجو برای: nimesulide
تعداد نتایج: 540 فیلتر نتایج به سال:
Sir, Acute renal failure (ARF) seen with non-steroidal anti-inflammatory drugs (NSAIDs) is mainly haemodynami-cally mediated due to inhibition of the synthesis of renal prostaglandins (PGs) w1x. Nimesulide is a new generation NSAID that differs from conventional NSAIDs in structure and pharmacological profile, claiming fewer side effects due to the specificity for the COX-2 enzyme w2x. We descr...
Effect of caffeine, norfloxacin and nimesulide on heartbeat and VEGF expression of zebrafish larvae.
The use of pharmaceuticals during pregnancy may causes abnormalities to the embryo. Sometime the drug also effect to the new born if the drug transferred through lactation. We have used zebrafish model to see the effect of some pharmaceuticals on embryos and larvae. Three drugs, caffeine, norfloxacin and nimesulide, were used for this study to see the effect mainly the hatching rate of eggs, he...
OBJECTIVE The aim of this study was to investigate the clinical effects of low-level laser therapy (LLLT) in patients with acute low back pain (LBP) with radiculopathy. BACKGROUND DATA Acute LBP with radiculopathy is associated with pain and disability and the important pathogenic role of inflammation. LLLT has shown significant anti-inflammatory effects in many studies. MATERIALS AND METHO...
We previously reported that epidermal growth factor (EGF)-induced esophageal cancer cell proliferation required transactivation of β-adrenoceptor. In the present study, we further investigated whether β2-adrenoceptor was involved in the modulation of cyclooxygenase-2 (COX-2) expression and cell proliferation by EGF in esophageal squamous cell carcinoma (ESCC). Human ESCC cell line KYSE-30 was t...
AIM Drug-induced liver injury is one of the most serious adverse drug reactions and the most frequent reason for restriction of indications or withdrawal of drugs. Some nonsteroidal anti-inflammatory drugs (NSAIDs) were withdrawn from the market because of serious hepatotoxicity. We estimated the risk of acute and serious liver injury associated with the use of nimesulide and other NSAIDs, with...
Cyclooxygenase (COX)-2 selective inhibitors suppress non-alcoholic fatty liver disease (NAFLD); however, the precise mechanism of action remains unknown. The aim of this study was to examine how the COX-2 selective inhibitor nimesulide suppresses NAFLD in a murine model of high-fat diet (HFD)‑induced obesity. Mice were fed either a normal chow diet (NC), an HFD, or HFD plus nimesulide (HFD-nime...
BACKGROUND Despite significant advances in diagnosis and therapy, the rate of survival of patients with oral cancers still remains poor as an appropriate treatment has not been found yet, due to side effects of chemo/radiotherapy. AIM This study aimed to identify molecular mechanisms of cell death of oral cancer cells caused by treatment with a nonselective Cox-2 inhibitor in combination with...
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