نتایج جستجو برای: nigrostriatal
تعداد نتایج: 1988 فیلتر نتایج به سال:
1,2,3,4-Tetrahydroisoquinoline (TIQ) has been reported to occur in human brain, with its content being 10-fold higher in the brain of a patient with Parkinson's disease (PD) than in that of a control subject. This congener of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) could be formed in brain by the condensation of phenylethylamine with metabolically formed formaldehyde....
Purpose: The motor control deficits exhibited with Parkinson’s disease (PD) are particularly well documented for sequencing tasks. The purpose of this study was to evaluate the neuroprotective potential of trans-resveratrol administration in an experimental model of PD. Materials and Methods: 1 week before (baseline) the surgery rats were tested with systemic apomorphine (0.5 mg/kg i.p.) to ev...
Parkinson's disease (PD) is a neurodegenerative disorder that results in the loss of nigrostriatal dopamine neurons. The etiology of this cell loss is unknown, but it involves abnormalities in mitochondrial function. In this study, we have demonstrated that the administration of a novel noncoding p137 RNA, derived from the human cytomegaloviral β2.7 transcript, can prevent and rescue dopaminerg...
The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal pathway. Here, we report that LPS-induced neuroinflammation in the striatum causes progressive degeneration of the dopamine nigrostriatal system, whi...
Purpose: The motor control deficits exhibited with Parkinson’s disease (PD) are particularly well documented for sequencing tasks. The purpose of this study was to evaluate the neuroprotective potential of trans-resveratrol administration in an experimental model of PD. Materials and Methods: 1 week before (baseline) the surgery rats were tested with systemic apomorphine (0.5 mg/kg i.p.) to ev...
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