When nicotinamide is injected into dogs, rats, or mice, there is a transient increase in the concentration of nicotinamide adenine dinucleotide in the liver (l-5). This phenomenon has been studied in great detail by Kaplan and his colleagues and has been the subject of a number of reviews (e.g. References 6 and 7). We have observed that the maximum level of NAD reached in response to nicotinami...

Objective(s):The present study investigated the antidiabetic and hypolipidemic properties of Dorema aucheri leave hydroalcoholic extract in nicotinamide-streptozotocin induced type 2 diabetic rats. Materials and Methods: nicotinamide/streptozotocin-induced diabetic rats were supplemented orally with three different doses of D.  aucheri (100, 200 and 400 mg/kg BW) or glibenclamide (0.25 mg/kg) f...

Phorbol ester-induced promotion of initiated NMRI mouse skin keratinocytes to papillomas could be largely prevented when nicotinamidelike inhibitors of poly(ADP-ribose)polymerase (nicotinamide, benzamide, 3-aminobenzamide) were applied simultaneously with 12-O-tetradecanoylphorbol-13-acetate(TPA). A similar suppression of tumor promotion by nicotinamide analogues was demonstrated in clone 41 JB...

The morphological effect of the nicotinamide analogue 6-aminonicotinamide on the development of the embryonic chick limb was studied, with special reference to muscle, cartilage, feather germ formation, and ossification. No evidence was found to support theories of control of differentiation by nicotinamide-like substances, although the effect of nicotinamide analogues has often been quoted as ...

We have extended our investigation of nicotinamide deamidation in the stomach of conventional rats. The bacterial species in the pars preventricularis were identified as Flavobacterium peregrinum, Escherichia coli, Streptococcus faecalis, and Lactobacillus acidophilus, listed in order of decreasing deamidase activity. Nicotinamide-7-(14)C ingested into rat stomach was rapidly deamidated to nico...

INTRODUCTION ...... ......... .......... .................. 83 BIOSYNTHESIS OF NICOTINAMIDE ADENINE DINUCLEOTIDE 83 Anaerobic De Novo Pathways .. ...... .... .... ... 84 Dihydroxyacetone phosphate-aspartate pathway 84 Formate-aspartate pathway .............................................. 87 Aerobic Tryptophan Catabolic Pathway 87 Genetics of Anaerobic Nicotinamide Adenine Dinucleotide Biosynt...

Dispersive liquid-liquid microextraction method (DLLME) combined with high-performance liquid chromatography-ultraviolet detection (HPLC-UV) was used to determine thiamine (B1), nicotinamide (B3) and pyridoxine (B6) in sour cherry juice. This method was rapid, simple and sensitive. Separation was accomplished using a C18 column. The optimum chromatographic conditions were found to be: mobile ph...