In the present work, various objective functions were formulated and optimized using mixed integer nonlinear programming generalized reduced gradient method from solver tool of Microsoft® Excel 2016, respectively. The CH3FO2, C2H4F2O, CH2F2O2, CH2F2O, C3H4F2, C2H2F2O molecules found to meet structural feasibility constraints physical properties refrigerant have not previously been reported in l...