نتایج جستجو برای: neutrophil gelatinase

تعداد نتایج: 43446  

2016
Kirsten J. Koymans Adinda Bisschop Mignon M. Vughs Kok P. M. van Kessel Carla J. C. de Haas Jos A. G. van Strijp

Matrix metalloproteinases (MMPs) are endopeptidases that degrade components of the extracellular matrix, but also modulate inflammation. During bacterial infections, MMPs are important in the recruitment and migration of inflammatory cells. Besides facilitating cell migration by degrading extracellular matrix components, they potentiate the action of several inflammatory molecules, including cy...

2016
Kim Hoenderdos Katharine M Lodge Robert A Hirst Cheng Chen Stefano G C Palazzo Annette Emerenciana Charlotte Summers Adri Angyal Linsey Porter Jatinder K Juss Christopher O'Callaghan Edwin R Chilvers Alison M Condliffe

BACKGROUND The inflamed bronchial mucosal surface is a profoundly hypoxic environment. Neutrophilic airway inflammation and neutrophil-derived proteases have been linked to disease progression in conditions such as COPD and cystic fibrosis, but the effects of hypoxia on potentially harmful neutrophil functional responses such as degranulation are unknown. METHODS AND RESULTS Following exposur...

2017
I.‐C. Wang W.‐L. Hsu P.‐H. Wu H.‐Y. Yin H.‐J. Tsai Y.‐J. Lee

BACKGROUND Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for the early prediction of renal damage and the progression of chronic kidney disease (CKD) in humans and dogs. HYPOTHESIS Neutrophil gelatinase-associated lipocalin also may play a role in the progression of CKD in cats. ANIMALS Eighty CKD and 18 control cats. METHODS Cats were categorized into different stages ...

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