Preclinical studies for boron neutron capture therapy (BNCT) using epithermal neutrons are ongoing at several laboratories. The absorbed dose in tumor cells is a function of the thermal neutron flux at depth, the microscopic boron concentration, and the size of the cell. Dosimetry is therefore complicated by the admixture of thermal, epithermal, and fast neutrons, plus gamma rays, and the array...

Determination of tumor boron-10 (10B) levels is required for accurate neutron dosimetry during boron neutron capture therapy. We assessed a new method for quantitative measurement of boronated drug uptake in high-grade gliomas. This method uses positron emission tomography (PET) with fluorine-18-labeled L-fluoroborono-phenylalanine (L-18F-10B-FBPA), which was synthesized as an analogue of L-bor...

In this paper an attempt is made to formulate criteria for the accuracy in the delivery of absorbed dose to a patient during photon or neutron therapy. These requirements are mainly based on the relative steepness of dose-effect curves for local tumour control and normal tissue damage. A review of these dose-effect curves after photon irradiation shows a great variety in steepness; the curves f...

background: in high-intensity, mixed and pulsed neutron fields the use of spectrometers or area monitors with active detectors is useless in these conditions neutron measuring devices must have a passive detector. here a passive neutron area monitor with cr39 track detector was designed and the response was calculated. materials and methods: the response of a passive neutron area monitor with c...