Anderson-Fabry disease (AFD) is an inborn error of glycosphingolipid metabolism that is due to a deficiency of the lysosomal hydrolase -galactosidase A ( -Gal A) (1). It is an X-linked lysosomal storage disorder (LSD) associated with multisystemic involvement resulting from the accumulation of neutral glycosphingolipids (mostly ceramide trihexoside [CTH]) in various organs (2). The disease mani...

Massless Dirac fermions in graphene at charge neutrality form a strongly interacting system in which both charged and neutral (energy) modes play an important role. These modes are essentially decoupled in the absence of a magnetic field, but become strongly coupled when the field is applied. We show that this regime is characterized by strong magnetodrag and Hall drag, originating from long-ra...

Although donor-acceptor (0-A) recombination UHP emission in semiconductors is reasonably well un2O~ ~ T’l.2K derstoo&, the processes contributing to the photo0 ~ production of the 0°-A°generators have not been o 489nm adequately explored. The interplay among exciton and charge carrier roles results in different spatial and neutral-pair-separation distributions 9 10 which are manifested in the s...

Energy Systems Modelling is growing in relevance on providing insights and strategies to plan a carbon-neutral future. The implementation of an effective energy transition faces multiple challenges, spanning from the integration operations different carriers sectors consideration spatial temporal resolutions. In this review, we outline these challenges discuss how they have been tackled by curr...

Coherent broadband radiation in the form of Rabi sidebands is observed when a ps probe laser propagates through a weakly ionized, electronically excited microplasma generated in the focus of an intense pump beam. The sidebands arise from the interaction of the probe beam with pairs of excited states of a constituent neutral atom via the probe-induced Rabi oscillation. Sideband shifting of >90 m...

We report the creation of an ultracold neutral plasma by photoionization of laser-cooled xenon atoms. The charge carrier density is as high as 2 3 109 cm23, and the temperatures of electrons and ions are as low as 100 mK and 10 mK, respectively. Plasma behavior is evident in the trapping of electrons by the positive ion cloud when the Debye screening length becomes smaller than the size of the ...

Members of the solute carrier family 6 (SLC6) sodium- and (sometimes chloride-) dependent neurotransmitter transporters [32, 2, 23, 75] are primarily plasma membrane located may be divided into four subfamilies that transport monoamines, GABA, glycine neutral amino acids, plus related bacterial NSS [109]. The members this superfamily share a structural motif 10 TM segments has been observed in ...

PURPOSE In this study, to optimize the polymeric drug delivery system for cancer chemotherapy, we developed a new pH-sensitive polymeric carrier, poly(vinylpyrrolidone-co-dimethylmaleic anhydride) [PVD], that could gradually release native form of drugs with full activity, from the conjugates in response to changes in pH. We examined the usefulness of PVD as a polymeric drug carrier. EXPERIME...

Rat liver mitochondria were loaded with aspartate by treating glutamate-loaded mitochondria with oxalacetate. Aspartate e&x was initiated by addition of extramitochondrial glutamate and was accompanied by the uptake of an equivalent amount of glutamate and protons. Proton uptake, however, did not occur in the presence of an uncoupling agent, and net transport of aspartate was facilitated by the...

In the context of global climate change and various environmental problems, stabilizing average temperature, implementing near zero carbon emissions, finally achieving absolute emissions in future have become an important task China’s ecological civilization construction. As population industrial cluster, park is carrier economic social activities, so most form to achieve dual goal. Based on bl...