In filamentous fungi, vegetative cell fusion between genotypically distinct individuals leads to a cell-death reaction known as vegetative or heterokaryon incompatibility. Genes involved in this reaction have been characterised molecularly. We can now begin to get a better understanding of the mechanism and the biological significance of this intriguing phenomenon.

The eukaryotic circadian clocks are composed of autoregulatory circadian negative feedback loops that include both positive and negative elements. Investigations of the Neurospora circadian clock system have elucidated many of the basic mechanisms that underlie circadian rhythms, including negative feedback and light and temperature entrainment common to all eukaryotic clocks. The conservation ...

Spore killer strains, found in Neurospora, provided the first recognized example of meiotic drive in fungi. In the present study, natural populations throughout the world were examined for the presence of killer strains and strains that are resistant to killing. In N. intermedia, Sk-2 and Sk-3 are present but are rare. Killer strains were found at only five sites, in Borneo, Java, and Papua New...

George Wells Beadle [7] and Edward Lawrie Tatum's 1941 article "Genetic Control of Biochemical Reactions in Neurospora [8]" detailed their experiments on how genes [9] regulated chemical reactions, and how the chemical reactions in turn affected development in the organism. Beadle and Tatum experimented on Neurospora, a type of bread mold, and they concluded that mutations to genes [9] affected...

1. A method was developed to examine the turnover of nitrate reductase by the use of tungstate. 2. Evidence is presented which suggests that the disappearance of nitrate reductase activity from Neurospora mycelia exposed to non-inducing conditions is due to the disappearance of the enzyme protein(s) from the mycelia, and not merely due to the disappearance of its (their) catalytic power. 3. The...

which had been added bovine serum albumin. The latter has been shown to aid in the preservation of Neurospora mitochondria capable of coupling oxidation to phosphorylation.4 It would seem then that the inclusion of bovine serum albumin in the medium has allowed us to isolate mitochondrial preparations capable of demonstrating substrate-independent amino acid production. Summary.-The mitochondri...

Until recently there has been no demonstrated case in Neurospora in which the loss of activity of an essential enzyme could be attributed to gene mutation. It has been assumed from indirect evidence1 that gene mutations do cause such losses and thereby result in “blocks” of essential biochemical reactions. The products of the “blocked” reactions thus become essential growth substances for the m...