Subretinal injections have been successfully used in both humans and rodents to deliver therapeutic interventions of proteins, viral agents, and cells to the interphotoreceptor/subretinal compartment that has direct exposure to photoreceptors and the retinal pigment epithelium (RPE). Subretinal injections of plasminogen as well as recent preclinical and clinical trials have demonstrated safety ...

Volume 11, Number 1, 2008 The anterior mandible is mostly considered as an idenal and safe area for rehabilitation of the edentulous mandible with oral implants. Nevertheless, the use of volumetric imaging has allowed the visualising of canal structures in the anterior mandible, which might assume some elaborate neurovascularisation. These findings may be linked to the fact that, in the past tw...

The pivotal role of the neurosensory retina in retinopathy of prematurity (ROP) disease processes has been amply demonstrated in rat models. We have hypothesized that analogous cellular processes are operative in human ROP and have evaluated these presumptions in a series on non-invasive investigations of the photoreceptor and post-receptor peripheral and central retina in infants and children....

Cisplatin is a chemotherapeutical agent that is highly effective in the treatment of solid organ tumours, such as ovarian, testicular, bladder, non-small cell pulmonary, and head and neck tumours. The main side effects associated with the use of cisplatin are gastrointestinal toxicity, nephrotoxicity, myelotoxicity, peripheral neurotoxicity and ototoxicity. Ototoxic lesions cause bilateral neur...

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 3 THE ROLES OF N-MYC AND L-MYC DURING INNER EAR NEUROSENSORY DEVELOPMENT by Benjamin Joseph Kopecky A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Biology in the Graduate College...

A solitary choroidal mass with an overlying neurosensory retinal detachment was seen in an otherwise healthy 25-year-old Caucasian female. Ocular and general physical examinations, serum chemistry, and pathological examination of a lymph node biopsy confirmed sarcoidosis as the cause for the choroidal mass. Treatment with systemic steroids resulted in resolution of the lesion and return of norm...

Hair cells of the developing mammalian inner ear are progressively defined through cell fate restriction. This process culminates in the expression of the bHLH transcription factor Atoh1, which is necessary for differentiation of hair cells, but not for their specification. Loss of several genes will disrupt ear morphogenesis or arrest of neurosensory epithelia development. We previously showed...

BACKGROUND Very preterm infants are at high risk for adverse neurodevelopmental outcomes. Magnetic resonance imaging (MRI) has been proposed as a means of predicting neurodevelopmental outcomes in this population. METHODS We studied 167 very preterm infants (gestational age at birth, 30 weeks or less) to assess the associations between qualitatively defined white-matter and gray-matter abnorm...

SUMMARY The presence of development disorders in neonates attended in a Neonatal Intensive Care Unit (NICU) is highly variable; the aim of this study, therefore, was to determine the evolution of somatic and neurosensory development in a group of neonates requiring treatment in the NICU and to analyse the perinatal and developmental aspects of children presenting abnormalities. PATIENTS AND M...

BACKGROUND Chronic exertional compartment syndrome (CECS) is characterized by elevated pressures within a closed space of an extremity muscular compartment, causing pain and/or disability by impairing the neuromuscular function of the involved compartment. The diagnosis of CECS is primarily made on careful history and physical exam. The gold standard test to confirm the diagnosis of CECS is inv...